一、个人简介

江晓闽，福建龙岩人，1995年生于福建漳州。2018年本科毕业于四川大学化学系，导师为袁立华教授。毕业后就读于美国芝加哥大学，师从Wenbin Lin教授，于2023年获得化学生物学博士学位。随后于美国芝加哥大学Ludwig Center for Metastasis Research开展肿瘤免疫学博士后研究，合作导师为Ralph R. Weichselbaum和Wenbin Lin教授。2025年1月加入西湖大学，担任助理教授、博士生导师，研究内容主要集中在开发新型纳米材料，以解决基因治疗和癌症免疫学等重大生物医学难题，并研究纳米医学中的药物作用机制。

二、学术成果

江晓闽博士专注于通过化学合成纳米材料，致力于提高药物在肿瘤部位的选择性积累，并开发新型医药手段以应对肿瘤药物递送的挑战。通过有机合成前药设计或无机配位药物的方法，将药物负载于纳米递送材料中，实现持续的肿瘤靶向和治疗。基于这些科学发现，江晓闽博士积极参与转化医学研究，成功开发了用于系统递送的新型候选药物，并已完成一期临床试验，预计将为多种晚期和转移性肿瘤提供新的治疗方案。其代表性学术成果包括：

1.    通过将易降解的免疫激动剂与无毒金属配位，成功开发出具有长效循环和肿瘤靶向性的纳米材料，并揭示了纳米医学在增强免疫激动剂抗肿瘤免疫效果中的新机制。

2.    研究了纳米配位聚合物材料在化疗药物递送中的机制，发现其与血液中的低密度脂蛋白相互作用，并依赖低密度脂蛋白受体发挥抗肿瘤效果。

3.    开发出具备药物修饰能力的纳米级金属有机框架材料体系，适用于肿瘤原位植入药物，延长药物在肿瘤部位的滞留时间，并增强其与放疗、化疗和免疫疗法的协同作用。

三、代表论文

1.    Xiaomin Jiang#, Taokun Luo#, Kaiting Yang, Morten J. Lee, Jing Liu, Langston Tillman, Wenyao Zhen, Ralph R. Weichselbaum, Wenbin Lin*. Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition for tumor eradication. Sci. Adv. 2024, 10, eado0082.

2.    Taokun Luo#, Xiaomin Jiang#, Yingjie Fan, Eric Yuan, Jinhong Li, Langston Tillman, and Wenbin Lin*. STING Agonist-Conjugated Metal-Organic Framework Induces Artificial Leukocytoid Structures and Immune Hotspots for Systemic Antitumor Responses. Natl. Sci. Rev. 2024, 10, nwae167.

3.    Taokun Luo#, Xiaomin Jiang#, Jinhong Li#, Geoffrey T. Nash, Eric Yuan, Luciana Albano, Langston Tillman, and Wenbin Lin*. Phosphate Coordination to Metal-Organic Layer Secondary Building Units Prolongs Drug Retention for Synergistic Chemoradiotherapy. Angew. Chem. Int. Ed. 2024, e202319981.

4.    Jing Liu#, Xiaomin Jiang#, Youyou Li, Kaiting Yang, Ralph R. Weichselbaum* and Wenbin Lin*. Immunogenic Bifunctional Nanoparticle Suppresses PD-L1 Expression in Tumor and Dendritic Cells to Elicit Adaptive Immunity and Potent Chemo-Immunotherapy. ACS Nano 2024, 18, 6, 5152–5166.

5.    Xiaomin Jiang#, Jing Liu#, Morten J. Lee, Cheng Peng, Taokun Luo, Langston Tillman, Ralph R. Weichselbaum, Wenbin Lin*. Nanoscale Coordination Polymer Synergizes Photodynamic Therapy and Toll-Like Receptor Activation for Enhanced Antigen Presentation and Antitumor Immunity. Biomaterials 2023, 302, 122334.

6.    Xiaomin Jiang#, Morten J. Lee#, Taokun Luo, Langston Tillman, Wenbin Lin*. Co-delivery of Three Synergistic Chemotherapeutics in A Core-Shell Nanoscale Coordination Polymer for the Treatment of Pancreatic Cancer. Biomaterials 2023, 301, 122235.

7.    Xiaomin Jiang#, Jianqiao Liu#, Jianming Mao, Wenbo Han, Yingjie Fan, Taokun Luo, Junjie Xia, Morten J. Lee, Wenbin Lin*. Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis. Biomaterials 2023, 295, 122037.

8.    Jing Liu#, Xiaomin Jiang#, Jianming Mao, Xuanyu Feng, Morten J. Lee, Youyou Li, Junjie Xia, Ralph R. Weichselbaum*, Wenbin Lin*. A Three-in-One Nanoscale Coordination Polymer for Potent Chemo-Immunotherapy. Small Method 2023, 2201437.

9.    Kaiting Yang#, Wenbo Han#, Xiaomin Jiang#, Andras Piffko, Jason Bugno, Chuanhui Han, Sirui Li, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Hua Liang, Jenny P.Y. Ting, Yang-Xin Fu, Wenbin Lin*, Ralph R. Weichselbaum*. Zinc-c-di-AMP Nanoparticles Target and Suppress Tumors via Endothelial STING Activation and Tumor Associated Macrophage Reinvigoration. Nat. Nanotech. 2022, 17, 1322-1331. (Highlighted by UChicago BSD News)

10. Xiaomin Jiang, Jianqiao Liu, Morten J. Lee, Junjie Xia, Taokun Luo, Megan Rodriguez, Wenbin Lin*. Two-stage Release of SN38 from a Core-shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade. ACS Nano 2022, 16, 21417–21430.

11. Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J. Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R. Weichselbaum, Wenbin Lin*. Tumor-Activatable Nanoparticles Target Low-Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy. Adv. Sci. 2022, 2201614.

12. Yingying Li#, Xiaomin Jiang#, Taokun Luo, Junjie Xia, Morten J. Lee, Ralph Weichselbaum, Wenbin Lin*. TLR3 Agonist Nanoscale Coordination Polymer Synergizes with Immune Checkpoint Blockade for Immunotherapy of Cancer. Biomaterials 2022, 290, 121831.

13. Xiaomin Jiang, Chunbai He, Wenbin Lin*. Supramolecular Metal-based Nanoparticles for Drug Delivery and Cancer Therapy. Curr. Opin. in Chem. Biol., 2021, 61, 143-153.

14. Xiang Ling#, Wenbo Han#, Xiaomin Jiang#, Megan Rodriguez, Pingping Zhu, Tong Wu, Wenbin Lin*. Point-source Burst of Coordination Polymer Nanoparticles for Tri-modality Cancer Therapy. Biomaterials 2021, 270, 120690.

国际专利申请

1)    Wenbin Lin, Xiaomin Jiang, Wenbo Han, Xuanyu Feng. Nanoparticles Containing Multiple Cleavable Prodrugs for Cancer Therapy. PCT Pub. No.: WO2022/040635.

2)    Wenbin Lin, Ralph R. Weichselbaum, Xiaomin Jiang, Kaiting Yang, Wenbo Han. ZnCDA for Immunotherapy of Cancer. Provisional patent.

四、联系方式

电子邮箱：jiangxiaomin@westlake.edu.cn