个人简介

李大鹏（1987-），山东泰安人。2005-2010年本科就读于南京农业大学动物医学院，获学士学位。2010-2016年博士就读于中国科学院上海巴斯德研究所，获博士学位。2017年加入杜克大学医学院人类疫苗研究所从事博士后研究工作，随后任杜克大学医学院讲师。2022年夏季全职加入西湖大学应急医学研究中心、生命科学学院，任博士生导师、助理教授一职。

学术成果及研究方向

李大鹏博士长期从事针对新发传染病的疫苗和抗体的研究，领域涉及冠状病毒、HIV、丙型肝炎病毒、埃博拉病毒等。代表工作包括：1) 新冠病毒与相关冠状病毒的抗体研究及疫苗开发；2) 丙型肝炎病毒和埃博拉病毒的疫苗开发与评价体系的建立；3) 对HIV感染者体内广谱中和抗体相关转录因子和免疫特征的鉴定；4) 针对NK细胞的免疫检查点抗体的开发与应用。

实验室将利用分子生物学、病毒学和免疫学的方法，结合系统生物学（抗体组学、转录组学等）与结构生物学，针对冠状病毒、黄病毒、新型布尼亚病毒等新发传染病和人畜共患传染病的病原，在以下几个方向进行研究：1) 新型疫苗（纳米颗粒疫苗、病毒载体疫苗、mRNA疫苗等）的设计开发及评价；2) 治疗性人源抗体的分离鉴定及基于结构的优化；3) 疫苗与抗体免疫保护机制的研究；4) 针对宿主因子或免疫检查点的新型免疫治疗策略的开发。

代表论文

* Co-first authors, ^#Co-corresponding authors.

1. Dapeng Li, David R Martinez, Alexandra Schäfer, Haiyan Chen, ..., Kevin O Saunders^#, Barton F Haynes^#. Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine. Nature Communications. 2022. 13, 6309. https://doi.org/10.1038/s41467-022-33985-4.

2. Dapeng Li*, Robert J. Edwards*, Kartik Manne*, David R. Martinez*, Alexandra Schäfer*, ..., Barton F. Haynes^#, Kevin O. Saunders^#. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell. 2021. 184(16):4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021

3. David R. Martinez*^#, Alexandra Schaefer*, Sophie Gobeil*, Dapeng Li*, …, Priyamvada Acharya^#, Barton F. Haynes^#, Ralph S. Baric^#. A broadly cross-reactive and neutralizing antibody protects against Sarbecovirus challenge in mice. Science Translational Medicine. 2022. 14, eabj7125. https://doi.org/10.1126/scitranslmed.abj7125 

4. Dapeng Li*, Simon Brackenridge*, Lucy C Walters*, …, Geraldine M. Gillespie^#, Andrew J. McMichael^#, Barton F. Haynes^#. Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity. Communications Biology, 2022. 5, 271. https://doi.org/10.1038/s42003-022-03183-5

5. Dapeng Li, Gregory D. Sempowski, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes^#. SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment. Annual Review of Medicine. 2022. 73:1-16. https://doi.org/10.1146/annurev-med-042420-113838

6. Dapeng Li*^#, Todd Bradley*, Derek W. Cain*, …, Barton F. Haynes^#. RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures. ImmunoHorizons. 2020. 4(11):713-728. https://doi.org/10.4049/immunohorizons.2000088

7. Todd Bradley*^#, Dimitra Peppa*, Isabela Pedroza-Pacheco*, Dapeng Li*, …, Persephone Borrow^#, Barton F. Haynes^#. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018. 175(2):387-399.e17. https://doi.org/10.1016/j.cell.2018.08.064

8. Tan Chen*, Dapeng Li*, Yufeng Song*, Xi Yang, Qingwei Liu, Xia Jin, Dongming Zhou^#, Zhong Huang^#. A heterologous prime-boost Ebola virus vaccine regimen induces durable neutralizing antibody response and prevents Ebola virus-like particle entry in mice. Antiviral Research. 2017. 145:54-59. https://doi.org/10.1016/j.antiviral.2017.07.009.

9. Dapeng Li, Xuesong Wang, Markus von Schaewen, Wanyin Tao, Yunfang Zhang, Brigitte Heller, Gabriela Hrebikova, Qiang Sun, Qiang Deng, Alexander Ploss^#, Jin Zhong^#, Zhong Huang^#. Immunization with a subunit hepatitis C virus vaccine elicits pan-genotypic neutralizing antibodies and intra-hepatic T-cell responses in non-human primates. The Journal of Infectious Diseases. 2017. 215(12):1824-1831. https://doi.org/10.1093/infdis/jix180

10. Dapeng Li, Markus von Schaewen, Xuesong Wang, Wanyin Tao, Yunfang Zhang, Li Li, Brigitte Heller, Gabriela Hrebikova, Qiang Deng, Alexander Ploss^#, Jin Zhong^#, Zhong Huang^#. Altered glycosylation patterns increase immunogenicity of a subunit HCV vaccine, inducing neutralizing antibodies which confer protection in mice. Journal of Virology. 2016. 90(23):10486-10498. https://doi.org/10.1128/JVI.01462-16.

11. Dapeng Li*, Tan Chen*, Yang Hu, Qingwei Liu, Dongming Zhou, Xia Jin, Zhong Huang. A novel reporter Ebola virus-like particle enabling in vivo infection and bioluminescent imaging of mice under non BSL-4 conditions. Journal of Virology. 2016. 90(19):8720-8. https://doi.org/10.1128/JVI.01239-16

12. Dapeng Li, Zhong Huang, Jin Zhong. Hepatitis C virus vaccine development: old challenges and new opportunities. National Science Review. 2015. 2:285–295. https://doi.org/10.1093/nsr/nwv040 

全部论文详见：

https://scholar.google.com/citations?user=CuUNSpcAAAAJ&hl=en

联系方式

电子邮箱：lidapeng@westlake.edu.cn