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Donut-shaped mitochondria from aged mother affect offspring body size.

个人简介

2005年毕业于华中师范大学生物技术专业。同年被保送入中国科学院生物物理所，于2010年获得中国科学院理学博士学位。自2011年，在哈佛大学医学院麻省总医院从事博士后研究，回国前任哈佛医学院医学系讲师。于2017年9月加入浙江西湖高等研究院（西湖大学前身），实验室主要在代谢与衰老领域开展研究。

学术成果及研究方向

实验室的研究致力于探索代谢与衰老相关疾病的发生和发展的分子机理，特别关注生命早期因素对成年健康和寿命的长期影响，以及代谢相关疾病的新型干预措施的研发。主要研究内容包括但不限于：1）探究成年健康与疾病的发育起源及其机制；2）研究生命早期线粒体稳态对健康与寿命的长远影响及其机制；3）开发精准营养策略以防治遗传突变引起的疾病。

代表性论文

1. Luxia Yao, Lei Wang, Runshuai Zhang, Alexander A Soukas*, Lianfeng Wu*. The direct targets of metformin in diabetes and beyond. Trends Endocrinol Metab, 2024, DOI: 10.1016/j.tem.2024.07.017.

2. Lei Wang#, Xianrong Zeng#, Yanjie Li, Wanyu Hao, Zijing Yu, Luxia Yao, Yongdeng Zhang, Zhaobin Wang*, Lianfeng Wu*. Chemical imaging unveils mitochondria as the major site of medicinal biguanide accumulation within cells. Heliyon, 2024, DOI: 10.1016/j.heliyon.2024.e34595.

3. Runshuai Zhang#, Jinan Fang#, Ting Qi#, Shihao Zhu, Luxia Yao, Guicun Fang, Yunsheng Li, Xiao Zang, Weina Xu, Wanyu Hao, Shouye Liu, Dan Yang, Di Chen, Jian Yang*, Xianjue Ma*, Lianfeng Wu*. Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria. Cell Research, 2023, 33: 821–834 (Featured Article, Cover Story).

4. Weixiang Bian#, Hua Jiang#, Luxia Yao, Wanyu Hao, Lianfeng Wu*, Xu Li*. A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling. Cell Reports, 2023, 42(7): 112819.

5. Luxia Yao#, Yihan Wang#, Shenlu Qin, Shihao Zhu, Lianfeng Wu*. The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA. Communications Biology, 2023, 6(1):96.

6. Shenlu Qin, Yihan Wang, Lili Li, Junli Liu, Congmei Xiao, Duo Duan, Wanyu Hao, Chunxia Qin, Jie Chen, Luxia Yao, Runshuai Zhang, Jia You, Ju-Sheng Zheng, Enzhi Shen, Lianfeng Wu*. Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans. Cell Reports, 2022, 40(12):111381(Featured Article).

7. Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu*, Xianjue Ma*, Junjie Chen*, Wenqi Wang*, Xu Li*. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell, 2021, 56(20): 2902-2919.

8. Runshuai Zhang#, Yuanzheng He#, Luxia Yao#, Jie Chen, Shihao Zhu, Xinxin Rao, Peiyuan Tang, Jia You, Guoqiang Hua, Lu Zhang, Feng Ju*, Lianfeng Wu*. Metformin chlorination byproducts in drinking water exhibit marked toxicities of a potential health concern. Environment International, 2021, 146: 106244.

9. Alexander A. Soukas*, Haibin Hao, Lianfeng Wu*. Metformin as Anti-Aging Therapy: Is It for Everyone? Trends Endocrinol Metab, 2019, 30(10): 745 - 755.

10. Lianfeng Wu, Ben Zhou, Noriko Oshiro-Rapley, Man Li, Joao A Paulo, Christopher M Webster, Fan Mou, Michael C Kacergis, Michael E Talkowski, Christopher E Carr, Steven P Gygi, Bin Zheng, Alexander A Soukas*. An ancient, unified mechanism for metformin growth inhibition in C. elegans and cancer. Cell, 2016, 167(7): 1705-1718 (Featured Article).

联系方式

　　电子邮箱：wulianfeng at westlake.edu.cn

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