个人简介

陶亮（1983-），浙江杭州人。2005年在中国科学技术大学获生命科学及计算机科学双学士学位，2010年于中国科学技术大学生命科学学院获生物学博士学位。2011-2017年在­堪萨斯大学医学中心和哈佛大学医学院从事博士后研究工作；2017年晋升哈佛医学院讲师。2018年9月全职加入西湖大学任研究员、博士生导师。

学术成果

陶亮博士一直致力于研究病原微生物和宿主之间的相互作用，尤其是从分子、生化、细胞、生信、遗传、结构等角度研究病原细菌毒素和效应蛋白对重要细胞功能的影响及作用机制。在基础研究同时，还从事开发各类细菌毒素衍生物分子用于科研、医学及商业领域。以第一或通讯作者在Cell, Nature, Science,  Nat Microbiol, Nat Electron, Cell Res, Nat Commun, Cell Discov, PLoS Pathog, mLife等学术期刊上发表论文四十余篇，申请或授权发明专利10项。获得过中国科学院院长奖、哈佛华人生命医学优秀学术奖、杭州西湖区“最美科技工作者”、杭州市十大青年科技英才提名奖等荣誉；入选“国家海外高层次人才引进计划”青年项目、“浙江省海外高层次引进计划”创新长期项目、浙江省杰出青年项目、浙江省高校领军人才培养计划。

课题组目前主要的研究方向包括：（1）细菌毒素对宿主细胞功能的影响和作用机制的研究；（2）微生物在宿主内的适应及与宿主环境平衡的研究；（3）细菌毒素蛋白的工程改造和应用开发。

代表性论文

(* Co-first author. ^# Corresponding author)

1. Li D*, Yang Q*, Luo J, Xu Y, Li J, Tao L^# (2024) Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation. Cell Discovery 10, 112

2. Lv X*, Zhang Y*, Sun K, Yang Q, Luo J, Tao L^#, Lu P^# (2024) De novo design of mini-protein binders broadly neutralizing Clostridioides difficile toxin B variants. Nature Communications 15: 8521

3. Zhou R*, He L*, Zhang J*, Zhang X, Li Y, Zhan X^#, Tao L^# (2024) Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin. Nature Communications 15: 1976

4. Zhou Y*, Zhan X*^#, Luo J, Li D, Zhou R, Zhang J, Pan Z, Zhang Y, Jia T, Zhang X, Li Y, Tao L^# (2023) Structural dynamics of CROPs control stability and toxicity of Paeniclostridium sordellii lethal toxin. Nature Communications 14: 8426

5. Luo J*, Yang Q*, Zhang X*, Zhang Y*, Wan L*, Zhan X, Zhou Y, He L, Li D, Jin D, Zhen Y, Huang J, Li Y^#, Tao L^# (2022) TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile. Cell 185(6): 980-984

6. Li X*, He L*, Luo J, Zheng Y, Zhou Y, Yang Q, Li D, Li Y, Tao L^# (2022) Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions. Nature Communications 13, 4331

7. Zhou Y*, Li D*, Luo J*, Chen A, Li X, Pan Z, Wan L, He L, Li D, Li Y, Dong M, Tao L^# (2021) Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin. Cell Research 31:935-938

8. Pan Z*, Zhang Y*, Luo J*, Li D, Zhou Y, He L, Yang Q, Dong M^#, Tao L^# (2021) Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology. PLoS Pathogens 17(1): e1009197

9. Shen E, Zhu K, Li D, Pan Z, Luo Y, Bian Q, He L, Song X, Zhen Y, Jin D, Tao L^# (2020) Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B. Communications Biology 3(1):347.

10. Tao L*^#, Tian S*, Zhang J*, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M^# (2019) Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nature Microbiology 4, 1760–1769.

11. Chen P*, Tao L*, Wang T, Zhang J, He A, Lam K, Liu Z, He X, Perry K, Dong M^#, Jin R^# (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science 360: 664-669.

12. Tao L*, Peng L*, Berntsson RP-A, Park S, Yu F, Boone C, Stenmark P^#, Krupp J^#, Dong M^# (2017) Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nature Communications 8, 53.

13. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup BW, Miao J, He X, Hurdle GJ, Breault TD, Brass AL, Dong M^# (2016) Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature 538:350-355.

Full publication: https://scholar.google.com/citations?hl=en&user=8gCEk_MAAAAJ

联系方式

电子邮箱：taoliang@westlake.edu.cn

实验室长期招聘博士后、博士研究生、科研助理，欢迎各方青年才俊的加入！