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Silent mutations can disrupt RNA modifications to promote tumorigenesis.

个人简介

　　谢琦（1984-），博士，浙江台州人。2007年本科毕业于中国农业大学生物学院，2012年于中国科学院生物物理研究所获得博士学位。2013-2019年在美国克里夫兰医学中心（Cleveland Clinic）和加州大学圣地亚哥分校（University of California San Diego，UCSD）从事博士后和助理项目科学家（Assistant Project Scientist）研究工作。谢琦博士于2019年8月全职加入西湖大学生命科学学院，担任研究员、助理教授（独立PI），博士生导师，2025年晋升为长聘副教授（Tenured Associate Professor）。

学术成果

谢琦课题组长期从事恶性肿瘤的调控机制与转化研究，近年来在癌症表观转录组学与免疫治疗领域取得一系列成果。在癌症表观转录组学方面：开发m⁶A精准编辑工具，被国内外研究者广泛使用（NAR，2021）；发现新型同义突变，提出“DNA突变-RNA修饰-功能表型”轴，丰富“中心法则”的理论内涵(Cell ,2025)。在免疫治疗方面：革新CAR T设计，以蛋白质设计的结合蛋白替代传统单链抗体（scFv），显著提升CAR T疗效并推进至临床试验(Nature Biomedical Engineering,2024)；通过CRISPR Screen发现多个增强CAR T效果的新靶点（Cancer Discovery,2021）。担任Cell等知名期刊审稿人，入选国家海外高层次人才引进计划（青年项目）和国家自然科学基金青年科学基金项目（A类）。课题组将继续秉承基础和转化相结合，解析癌症表观转录组和基因组的互作机制，拓展免疫治疗新策略，为癌症精准诊疗提供理论依据和技术支撑。

代表论文

(1) Yiheng Lan*; Zhen Xia*; Qizhe Shao*; Peng Lin; Jinhong Lu; Xiaoying Xiao; Mengyue Zheng; DiChen#; Yanmei Dou#; Qi Xie #; Synonymous mutations promote tumorigenesis by disrupting m6A-dependent mRNA metabolism, Cell, 188 (7), 1828-1841

(2) Zhen Xia*; Qihan Jin*; Zhilin Long; Yexuan He; Fuyi Liu; Chengfang Sun; Jinyang Liao; Chun Wang; Chentong Wang; Jian Zheng; Weixi Zhao; Tianxin Zhang; Jeremy N.Rich; Yongdeng Zhang; Longxing Cao#; Qi Xie #; Targeting overexpressed antigens in glioblastoma via CAR T cells withcomputationally designed high-affinity protein binders, Nature Biomedical Engineering, 2024，8 (12), 1634-1650

(3) Xiaojuan Ran; Jian Zheng; Lingchao Chen; Zhen Xia; Yin Wang; Chengfang Sun; Chen Guo; Peng Lin; Fuyi Liu; Chun Wang; Jianguo Zhou; Chongran Sun; Qichang Liu; Jianzhu Ma; Zhiyong Qin#; Xiangdong Zhu#; Qi Xie #; Single-cell transcriptomics reveals the heterogeneity of the immune landscape of IDH-wildtype high-grade gliomas, Cancer Immunology Research, 2023, 12(2): 232-246

(4) Zhen Xia; Min Tang; Jiayan Ma; Hongyan Zhang; Ryan C. Gimple; Briana C. Prager; HongzhenTang; Chongran Sun; Fuyi Liu; Peng Lin; Yutang Mei; Ruoxin Du; Jeremy N. Rich; Qi Xie# ;Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase, Nucleic Acids Research, 2021, 49(13): 7361-7374

(5) Dongrui Wang*; Briana C. Prager*; Ryan C. Gimple; Brenda Aguilar; Darya Alizadeh; HongzhenTang; Deguan Lv; Renate Starr; Alfonso Brito; Qiulian Wu; Leo J. Y. Kim; Zhixin Qiu; Peng Lin;Michael H. Lorenzini; Behnam Badie; Stephen J. Forman; Qi Xie#; Christine E. Brown#; Jeremy N. Rich#; CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies, Cancer Discovery, 2021, 11(5): 1192-1211

(6) Qiao Lu*; Jia Liu*; Shuai Zhao*; Maria Florencia Gomez Castro; Maudry Laurent-Rolle; Jianbo Dong; Xiaojuan Ran...Siyuan Ding#; Qi Xie#; Jun Wang# ; SARS-CoV-2exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2, Immunity, 2021, 54(6): 1304-1319.e9

(7) Peng Lin*; Wenyan Chen*; Zhilin Long; Jichuan Yu; Jiayao Yang; Zhen Xia; Qiulian Wu; Xinyu Min; Jing Tang; Ya Cui; Fuyi Liu; Chun Wang; Jian Zheng; Wei Li; Jeremy N. Rich#; Lei Li#; Qi Xie#; RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation, Cell Discovery, 2024, 10(1)

(8) Qi Xie; Tao P. Wu*; Ryan C. Gimple*; Zheng Li; Briana C. Prager; Qiulian Wu; Yang Yu; Pengcheng Wang; Yinsheng Wang; David U. Gorkin; Cheng Zhang; Alexis V. Dowiak; Kaixuan Lin; Chun Zeng; Yinghui Sui; Leo J. Y. Kim; Tyler E. Miller; Li Jiang; Christine H. Lee; Zhi Huang; Xiaoguang Fang; Kui Zhai; Stephen C. Mack; Maike Sander; Shideng Bao; Amber E. Kerstetter-Fogle; Andrew E. Sloan; Andrew Z. Xiao; Jeremy N. Rich; N-6-methyladenine DNA Modification in Glioblastoma, Cell, 2018, 175(5): 1228-1243

(9) Briana C. Prager*; Qi Xie*; Shideng Bao; Jeremy N. Rich ; Cancer Stem Cells: The Architects of the Tumor Ecosystem, Cell Stem Cell, 2019, 24(1): 41-53

(10) Zhilin Long; Chengfang Sun; Min Tang; Yin Wang; Jiayan Ma; Jichuan Yu; Jingchao Wei; Jianzhu Ma; Bohan Wang#; Qi Xie#; Jiaming Wen#; Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma, Cell discovery, 2022, 8(1)

联系方式

　　电子邮箱 ：xieqi@westlake.edu.cn

实验室网站：https://xieqi.lab.westlake.edu.cn/