个人简介

　　许田， 1982年复旦大学学士，1990年耶鲁大学博士 , 1990-1993年加州大学伯克利分校博士后。1993-2018年历任耶鲁大学遗传学和神经生物学助理教授、副教授、终身教授、C.N.H. Long讲席教授，2003-2018年任耶鲁大学遗传学系副系主任，2001-2013年任耶鲁大学校长顾问。1997-2018年任霍华德休斯医学研究院研究员。2018年4月全职加入西湖大学，任遗传学讲席教授、副校长。国务院侨办专家咨询委员会委员、海协会理事、美国科学促进会成员（AAAS Fellow）。曾任华人生物学家协会主席。曾获美国优秀博士后奖（Whitney）、优秀青年科学家学者（Pew）、结节性硬化症协会创新奖和杰出贡献等奖。对教育情有独钟，其主持遗传学课是二十年来耶鲁最热门课程之一。获耶鲁优秀博士论文导师、美国索恩本遗传讲座奖。1996年起每年在复旦、科学院等大学和院所讲学。创建复旦发育生物学研究所。积极推动中美交流，长期担任耶鲁校长中国事务顾问，推动耶鲁与中国重新建立密切友好关系，为美国科技教育界与中国交流作出表率。推动和参与耶鲁与中国各项交流和合作，包括大学校长研讨班、高级领导研讨班、高级女干部研讨班、胡锦涛主席访问耶鲁、耶鲁百人访华等活动。曾任美中前沿科学交流委员会美方主席 。

学术成果

　　许田教授主要开展生长调控领域和遗传学方法的研究，为生长调控领域的创始人之一，该领域的重要调控基因和信号转导通道均为其实验室首先发现，为发育和疾病提供新理论和机理，为癌症和十多种罕见病诊断和二十多种药物的研发作出贡献。拥有几十项国际专利，哺乳动物转座子和镶嵌遗传分析等多项发明为全世界广为应用，并成功产业化。2002-2018年担任罗斯伯格研究所/孵化器科学委员会主席，富有成效地推动了生物科技产业化，多家科技公司的创始人和顾问。曾长期担任Cell、Annual Review of Genetics、Molecular Cancer Research、iBiology、The International Journal of Biological Sciences等杂志编委，Disease Models and Mechanisms创刊编委。

代表性论文

1. Xu C, Fan J, Liu D, Tuerdi A, Chen J, Pan Y, Dang H, Wei X, Yousif AS, Yogaratnam J, Zhou Q, Lichenstein H, Xu T*.   Alpha-kinase 1 (ALPK1) agonist DF-006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B. Hepatology 2023 Jan 1;77(1):275-289.

2. Dong YL, Vadla GP, Lu JY, Ahmad V, Klein TJ, Lu-Fang Liu LF, Glazer PM, Xu T*, Chabu CY*.  Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance. Commun. Biol. 2021, 4(1):374.

3. Chang H,Pan Y, Landrette S, Yang D, Ding S, Liu L, Tian L, Li D, Xu T*. Efficient genome-wide first-generation phenotypic screening system in mice usingpiggyBactransposon. PNAS 2019,116(37):18507-18516.

4. Dunn BS,  Rush L, Lu JY, Xu  T*. Mutations in  the tricellular junction protein M6 synergize with to induce apical cell  delamination and invasion. PNAS 2018,115(33),8358-8363

5. Chabu C, Li  DM, Xu  T*. EGFR/ARF6  regulation of Hh signalling stimulates oncogenic Ras tumour  overgrowth. Nature  Communications 2017,8:  14688

6. Jin Y, Chen  Y, Zhao S, Guan KL, Zhuang Y, Wu X, Xu  T*. DNA-PK  Facilitates piggyBac Transposition by Promoting Paired-End Complex  Formation. PNAS 2017,  11;114(28):7408-7413.

7. Willsey RH,  Zheng X, Carlos Pastor-Pareja J, Willsey AJ, Beachy PA, Xu  T*. Localized JNK  signaling regulates organ size during development. elife. 2016,  14;5.

8. Olds WH  & Xu  T*. Regulation of  Food Intake by Mechanosensory Ion Channels in Enteric Neurons.   eLife 2014,  6;3.

9.  Pastor-Pareja JC & Xu  T*. Shaping cells  and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and  Perlecan. Development  Cell 2011,  21(2):245-56.

10. Wu  M, Pastor-Pareja  JC, Xu  T*. Interaction  between Ras(V12) and scribbled clones induces tumour growth and  invasion. Nature 2010,  463(7280): 545-U165

11. Igaki T.,  Pastor-Pareja, JC., Aonuma, H., Miura M. and Xu  T*. Intrinsic  tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Development  Cell 2009,  16(3):458-65.

12. Xue  L, Igaki T,  Kuranaga E, Kanda  H, Miura  M, Xu  T*. Tumor  suppressor CYLD regulates JNK-induced cell death in  Drosophila. Developmental  Cell 2007,13(3):  446-454.

13. Ding  S, Wu  X, Li G, Han M,  Zhuang Y, Xu  T*. Efficient  transposition of the piggyBac (PB) transposon in mammalian cells and  mice. Cell 2005,122(3):  473-483

14. Yang XL, Yu  KP, Hao YW, Li D-M, Stewart R, Insogna KL, Xu  T*. LATS1 tumor  suppressor affects cytokinesis by inhibiting LIMK1. Nature Cell  Biology 2004,  6:609-617. PMID:15220930.

15. Pagliarini RA, Xu  T*. A genetic  screen in Drosophila for metastatic behavior. Science 2003, 302(5648):  1227-1231

16. Potter  CJ, Pedraza LG, Xu  T*. Akt regulates  growth by directly phosphorylating Tsc2. Nature Cell  Biology 2002, 4(9):  658-665

17. Zhang S, Xu  L, Lee J, Xu  T*. Drosophila Atrophin  homolog functions as a transcriptional co-repressor in multiple developmental  processes. Cell 2002,  108:45-56.

18. Potter CJ,  Huang H, Xu T*. Drosophila  Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell  growth, cell proliferation, and organ size. Cell 2001,  105:357-368.

19. Tao W,  Zhang S, Turenchalk GS, Stewart RA, St. John MAR, Chen W, Xu  T*. Human  homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2  activity. Nature  Genetics 1999,  21:177-181.

20. St. John  MAR, Tao W, Fei X, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath  J, Xu  T*. Mice  deficient for Lats1 develop soft tissue sarcomas, ovarian tumors and pituitary  dysfunction. Nature  Genetics 1999,  21:182-186.

21. Huang H,  Potter CJ, Tao W, Li D-M, Brogiolo W, Hafen E, Sun H, Xu  T*. PTEN affects  cell size, cell proliferation and apoptosis during Drosophila eye  development. Development 1999, 126:  5365-72.

22. Rooke J, Pan D, Xu T*, Rubin GM.  KUZ, a conserved metalloprotease/disintegrin protein, plays two distinct roles during Drosophila neurogenesis.   Science 1996,  273:1227-1231. PMID: 8703057.

23. Xu T*, Wang W, Zhang  S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics:  the Drosophila lats gene  encodes a putative protein kinase. Development 1995,  121:1053-1063.

24. Xu T and Rubin GM. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 1993, 117:1223-1237.

联系方式

　　电子邮箱：xutian@westlake.edu.cn

　　许田教授课题组将继续生长调控和遗传学机理的研究和转化，包括器官尺寸和生长调控的发育、遗传、疾病（癌症和罕见病）的机理以及新药靶、药物和转座子基因治疗手段的开发。
　　课题组展开意识的物质基础的新领域探索，结合模式生物遗传学、神经生物学、疾病心理学和人工智能进行自我意识生物学机理的研究和模拟。
　　课题组诚聘生物医药、神经生物学和计算机科学杰出人才作为Co-PI，同时招聘研究员、副研究员、博士后、博士研究生、助理研究员、科研助理以及行政助理。具体岗位职责和应聘条件参见以下招聘链接：

https://www.westlake.edu.cn/Careers/OpenPositions/research/202009/t20200925_7185.shtml 

https://www.westlake.edu.cn/Careers/OpenPositions/PostDoctoral/202007/t20200724_6744.shtml

附西湖大学招生信息：
　　https://www.westlake.edu.cn/admissions_aid/graduate/