个人简介

王兆彬，2011年毕业于南京大学，获得学士学位。2015年毕业于香港科技大学，获得博士学位，师从孙建伟教授。2016至2019年，在美国加州理工学院（Caltech）从事博士后研究，师从Gregory C. Fu 教授。2019年10月加入西湖大学理学院任特聘研究员，开展独立研究工作。

学术成果

在生物体中，手性物质广泛存在，并具有重要的生物学意义。高效、精准的手性合成在药物研发、材料科学、农药开发等领域具有非常重要的价值。王兆彬博士主要从事不对称催化方面相关研究。迄今，先后发展了一系列手性布朗斯特酸催化的不对称开环反应和对于亚甲基苯醌类化合物的不对称加成反应。此外，还成功实现了一系列金属镍催化的手性汇聚交叉偶联反应，将烷基卤代物及简单易得的原料，高效转化为高附加值手性产物。相关研究成果已发表在Nature, Nat. Chem., J. Am. Chem. Soc. 和Angew. Chem. Int. Ed. 等化学顶尖杂志上。

代表论文（*代表通信作者）

1.      Lv, Y.-F.^#; Liu, G.^#; Shi, Z.; Wang, Z.* “Chromium Catalyzed Asymmetric Reformatsky Reaction” Angew. Chem. Int. Ed. 2024, doi.org/10.1002/anie.202406109. (^# co-first author)

2.      Hu, H.^#; Shi, Z. ^#; Guo, X. ^#;Zhang, F.-H.; Wang, Z.* “A Radical Approach for Asymmetric α-C–H Addition of N-Sulfonyl Benzylamines to Aldehydes” J. Am. Chem. Soc. 2024, 146, 5316-5323. (^# co-first author)

3.      Shen, H.; Zhang, Z.; Shi, Z.; Gao, K.; Wang, Z.* “A Modular Approach to Stereoselective Homoaldol Reaction via Photoredox/Cr/Co Triple Catalysis” Chem 2024, 10, 998-1014.

4.      Zeng, X.^#; Zhang, F.-H. ^#; Lai, R.; Lin, X.; Wang, Z.* “Cr-Catalyzed Allylic C(sp³)–H Addition to Aldehydes Enabled by Photoinduced Ligand-To-Metal Charge Transfer” Sci. China Chem. 2024, 67,1589-1595. (^# co-first author)

5.      Hu, H.; Wang, Z.* “Cr-Catalyzed Asymmetric Cross Aza-Pinacol Couplings for β-Amino Alcohol Synthesis” J. Am. Chem. Soc. 2023, 145, 20775-20781.

6.      Ni, J.^#; Xia, X. ^#; Wang, Z.* “Ti-Catalyzed Modular Ketone Synthesis from Carboxylic Derivatives and gem-Dihaloalkanes” J. Am. Chem. Soc. 2023, 145, 14884-14893. (^# co-first author)

7.      Liu, H.-L.; Wang, X.; Gao, K.; Wang, Z.* “Catalytic Diastereo- and Enantioselective Cyclopropanation of gem-Dihaloalkanes and Terminal Olefins” Angew. Chem. Int. Ed. 2023, 62, e202305987.

8.      Guo, X.^#; Shi, Z. ^#; Zhang, F.-H.; Wang, Z.* “Cr-Catalyzed Regio-, Diastereo- and Enantioselective Reductive Couplings of Ketones and Propargyl Halides” ACS Catal. 2023, 13, 3170-3178. (^# co-first author)

9.      Xia, X.; Wang, Z.* “Cr-Catalyzed Diastereo- and Enantioselective Synthesis of β-Hydroxy Sulfides and Selenides” ACS Catal. 2022, 12, 11152-11158.

10.   Zhang, F.-H.; Guo, X.; Zeng, X.; Wang, Z.* “Asymmetric 1,4-Funcitonalization of 1,3-Enynes via Dual Photoredox and Chromium Catalysis” Nat. Commun. 2022, 13, 5036.

11.   Ni, J.; Xia, X.; Zheng, W.-F.; Wang, Z.* “Ti-Catalyzed Diastereoselective Cyclopropanation of Carboxylic Derivatives with Terminal Olefins” J. Am. Chem. Soc. 2022, 144, 7889-7900.

12.   Zhang, F.-H.; Guo, X.; Zeng, X.; Wang, Z.* “Catalytic Enantioconvergent Allenylation of Aldehydes with Propargyl Halides” Angew. Chem. Int. Ed. 2022, 61, e202117114.

13.   Wang, Z.; Yang, Z-P.; Fu, G. C.* “Quaternary Stereocentres via Catalytic Enantioconvergent Nucleophilic Substitution Reactions of Tertiary Alkyl Halides by Alkenylmetal Reagents” Nat. Chem. 2021, 13, 236−242.

14.   Wang, Z.; Yin, H.; Fu, G. C.* “Catalytic Enantioconvergent Couplings of Secondary and Tertiary Electrophiles with Olefins” Nature 2018, 563, 379−383.

15.   Wang, Z.; Bachman, S.; Dudnik, A. S.; Fu, G. C.* “Nickel-Catalyzed Enantioconvergent Borylation of Racemic Secondary Benzylic Electrophiles”, Angew. Chem. Int. Ed. 2018, 57, 14529−14532.

16.   Wang, Z.; Wong, Y. F.; Sun, J.* “Catalytic Asymmetric 1,6-Conjugate Addition of para-Quinone Methides: Formation of All-Carbon Quaternary Stereocenters”, Angew. Chem., Int. Ed. 2015, 54, 13711−13714.

17.   Wang, Z.; Sheong, F.; Sung, H.; Williams, I.; Lin, Z.*; Sun, J.* “Catalytic Enantioselective Intermolecular Desymmetrization of Azetidines”, J. Am. Chem. Soc. 2015, 137, 5895−5898.

18.   Wang, Z.; Ai, F.; Wang, Z.; Zhao, W.; Zhu, G.*; Lin, Z*.; Sun, J.* “Organocatalytic Asymmetric Synthesis of 1,1-Diarylethanes by Transfer Hydrogenation”, J. Am. Chem. Soc. 2015, 137, 383−389.

19.   Wang, Z.; Chen, Z.; Sun, J.* “Catalytic Enantioselective Intermolecular Desymmetrization of 3-Substituted Oxetanes”, Angew. Chem. Int. Ed. 2013, 52, 6685−6688. (Front cover, highlighted in SYNFACTS)

20.   Wang, Z.; Sun, J.* “Enantioselective [4+2] Cycloaddition of o-Quinone Methides and Vinyl Sulfides: Indirect Access to Generally Substituted Chiral Chromanes”, Org. Lett. 2017, 19, 2334−2337.

21.   Wang, Z.; Law, W. K.; Sun, J.* “Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of meso-Epoxides by Thiols”, Org. Lett. 2013, 15, 5964−5966.

22.   Chen, Z.¹; Wang, Z.¹ (co-first author); Sun, J.* “Catalytic Enantioselective Synthesis of Tetrahydroisoquinolines and Their Analogues Bearing a C4 Stereocenter: Formal Synthesis of (+)-(8S, 13R)-Cyclocelabenzine”, Chem. −Eur. J. 2013, 19, 8426−8430. (1: equal contribution)

联系方式

电子邮箱：wangzhaobin@westlake.edu.cn

本课题组旨在研究绿色、高效的不对称催化合成方法，主要涉及有机小分子催化、过渡金属催化及自由基化学等，并致力于所发展合成方法在生物化学及材料化学中的应用研究。

课题组招生招聘：

1. 博士后招聘（长期有效）：有机化学研究背景的博士毕业生，提供优厚个人待遇和补助（享受杭州市博后补贴，欢迎咨询）。

2. 博士生招生：欢迎对有机化学感兴趣的本科生或者硕士生申请博士研究生。

3. 本科生短期项目：欢迎本科生加入科研实习及毕业设计。