时间：8月3日星期二16:00-17:30    

Time：4:00-5:30 PM，Tues., August 3th，2021

地点：西湖大学云栖校区3号楼312会议室

Venue: Room 312, 3F, Building 3, Yunqi Campus

主持人：西湖大学生命科学学院研究员 何丹阳

Host：Dr. Danyang He, School of Life Sciences

主讲嘉宾/Speaker:

Dr. Bo Peng

Principal Investigator, Fudan University

Dr.

Dr. Bo Peng is an awardee of the Excellent Young Scholar Grant of NSFC. He obtained his bachelor degree of biotechnology in 2008 at Huazhong University of Science and Technology. He then studied neurophysiology at Institute of Neuroscience at Chinese Academy of Sciences from 2008 to 2011. After that, he investigated retinal degenerative disorders at The University of Hong Kong and obtained his Ph.D. degree in neuroscience at 2015. After that, Dr. Bo Peng joined Shenzhen Institutes of Advanced Technology at Chinese Academy of Sciences as an associate professor and established his own lab. In 2019, Dr. Bo Peng moved to Fudan University as a professor.

Dr. Bo Peng's laboratory is mainly focusing on deciphering the origin and function of microglia in the central nervous system (CNS). In addition, his lab is developing therapeutic approaches for treating CNS disorders. Dr. Bo Peng published series of last author papers, including in Nature Neuroscience and Cell Reports.

讲座摘要/Abstract:

Microglia   are important immune cells in the central nervous system (CNS). Newborn   microglia rapidly replenish the whole brain after selective elimination of   most microglia (>99%) in adult mice. Previous studies reported that   repopulated microglia were largely derived from microglial progenitor cells   expressing nestin in the brain. However, the origin of these repopulated   microglia has been hotly debated. In our study, we investigated the origin of   repopulated microglia by a series of fate-mapping approaches. We first   excluded the blood origin of repopulated microglia via parabiosis. With   different transgenic mouse lines, we then demonstrated that all repopulated   microglia were derived from the proliferation of the few surviving microglia   (<1%). Despite a transient pattern of nestin expression in newly forming   microglia, none of repopulated microglia were derived from nestin-positive   non-microglial cells. We thus conclude that repopulated microglia are solely   derived from residual microglia rather than de novo progenitors, suggesting   the absence of microglial progenitor cells in the adult brain.   

As important immune cells, dysfunctions of gene-deficient microglia   contribute to the development and progression of multiple CNS diseases.   Microglia replacement by nonself cells has been proposed to treat   microglia-associated disorders. However, some attempts have failed due to low   replacement efficiency, such as with the traditional bone marrow   transplantation approach. Based on our understanding of microglial   repopulation, we develop three efficient strategies for microglia   replacement: microglia replacement by bone marrow transplantation (Mr BMT),   microglia replacement by peripheral blood (Mr PB), and microglia replacement   by microglia transplantation (Mr MT). Mr BMT and Mr PB allow microglia-like   cells to efficiently replace resident microglia in the whole CNS. On the   other hand, Mr MT achieves microglia replacement in brain regions of   interest. In summary, the present study offers effective tactics for   microglia replacement with diverse application scenarios, which potentially   opens up a window on treating microglia-associated CNS disorders.    

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn