时间：9月19日星期二16:00-17:30

Time：4:00-5:30 PM，Tuesday, September 19，2023

主持人：西湖大学生命科学学院讲席教授 裴端卿

    Host：Dr. Duanqing Pei, Chair Professor, School of Life Sciences

    地点：云谷校区E9-109

    Venue：E9-109, Yungu Campus

主讲嘉宾/Speaker:

Dr. Peng-Yuan Wang, Principal Investigator, Oujiang Laboratory; Professor, Key Laboratory of Alzheimer's Disease of Zhejiang, Institute of Aging, Wenzhou Medical University

Dr Wang was awarded the China high-level overseas talent, ARC DECRA Fellow, and Victoria Young Scientist in Australia. After returning to China, he served as PI at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, and as Director of Shenzhen Key Laboratory. He joined Oujiang Laboratory and Wenzhou Medical University at the end of 2021. Dr. Wang has presided over a number of National Grants, including the National Key R&D Programs, the Natural Science Foundation project, the International Cooperation project of the Chinese Academy of Sciences and Zhejiang Province, etc. His research interest is stem cells and engineering biology, focusing on the advanced materials fabrication and mechanism of biophysical effects on cell fate regulation, aiming to improve cell differentiation efficiency and transdifferentiation through defined stimulations. Combination approaches of biophysics and biochemistry have great potential in cell production, which benefit cell therapy and regenerative medicine.

讲座摘要/Abstract:

Cell fate manipulation is a critical process in cell production and regenerative medicine. Efficient strategies in maintaining the stemness of stem cells or differentiating stem cells into specific cell types are still limited. To date, studies have reported that biophysical cues in the form of nanotopographies can influence stem cell attachment, proliferation, and differentiation. Specific surface nanotopographies can enhance the efficiency of cell reprogramming or maintain the stemness of stem cells. While biochemical cues are generally efficient, biophysical cues have advantages such as scalability, cost-effectiveness, longer lifetime, and ease of definition. In our group, several biomimetic structures, including nanogrooves, nanopillars, nanopores, and colloidal crystals, have been fabricated using various nanotechnologies. Our findings show that we can direct cell fate and phenotype through defined physicochemical cues, which reveals the fundamental questions in cell biology and benefits cell-based therapies. We believe that combining optimal biophysical cues with current biological approaches has great potential to improve efficiency and generate functional cells.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn