时间：2019年11月15日（周五）上午14:00-15:30
　　Time：2:00-3:30 PM, Friday, Nov 15, 2019
　　地点：西湖大学云栖校区3号楼312会议室
　　Venue:Room 312, 3F, Building 3, Yunqi Campus
　　主持人：西湖大学生命科学学院讲席教授 许田
　　Host:Tian Xu, Chair Professor of School of Life Sciences, Westlake University

主讲人/Speaker：Kun-Liang Guan, PhD, Professor, Department of Pharmacology, University of California, San Diego, USA
　　Kun-Liang Guan is a Distinguished Professor in the Department of Pharmacology, UCSD. He received his BS (1982) from Hangzhou University, China and his PhD (1989) from Purdue University. He was a faculty at University of Michigan (1992-2007) and joined UCSD in 2007. Guan studies signaling mechanisms in cell growth and tumorigenesis, particular focusing on the mTOR and Hippo pathways. He is one of the most highly cited researchers in Molecular Biology & Genetics.
　　

报告题目/Title:
　　The Hippo Pathway in Cell Growth, Organ Size, and Tumorigenesis
　　

讲座摘要/Abstract:
　　The Hippo pathway is crucial in organ size control and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include the protein kinases of MST1/2, MAP4Ks, LATS1/2, the transcription co-activators YAP/TAZ and their DNA binding partners TEADs. LATS phosphorylates YAP/TAZ to promote cytoplasmic localization and degradation, thereby inhibiting YAP/TAZ and cell growth. The TEAD transcription factors also shuttle between nuclear and cytoplasm in a Hippo independent manner. The Hippo pathway is regulated by a wide range of signals, including cell density, GPCR, cellular energy levels, and mechanical cues. The emerging role of the Hippo pathway in tumorigenesis suggests potential therapeutic value of targeting this pathway for cancer treatment. The lecture will focus on the regulatory mechanisms and biological functions of the Hippo pathway.
　　

讲座联系人/Contact:
　　科技合作部 毕老师
　　biguanying@westlake.edu.cn