时间：2019年8月1日（周四）上午09:00-10:30
　　Time：09:00-10:30, Thursday, August 1, 2019
　　地点：西湖大学云栖校区5号楼一楼报告厅
　　Venue:Lecture Hall, 1stFloor, Building 5, Yunqi Campus
　　主持人：许田教授
　　Host:Prof. Tian Xu
　　主讲嘉宾/Speaker：

　　Jun Lu, Ph.D.
　　Associate Professor of Genetics
　　Yale Department of Genetics and Stem Cell Center
　　

主讲人简介/Biography:
　　Dr. Jun Lu is an Associate Professor of Genetics at Yale University School of Medicine. He is a Core Member of Yale Stem Cell Center, and a member of Yale Cancer Center and Yale Center for RNA Science and Medicine. Dr. Lu is an Associate Director of the Cell Preparation and Analysis Core of the NIDDK-funded Yale Cooperative Center of Excellence in Hematology. Dr. Lu received his B.S. degree in 1997 from Nanjing University in China. He obtained doctoral degree in biochemistry at Boston University in 2003 and received postdoctoral training at the Broad Institute in Boston. Dr. Lu’s laboratory studies gene regulatory mechanisms involving small noncoding RNAs and epigenetic pathways. His laboratory uses multi-disciplinary approaches, including computational biology and wet-lab experiments, to reveal regulatory mechanisms in the areas of hematopoiesis and cancer immunology. Dr. Lu was an Alexander and Margaret Stewart Trust Fellow and a William Guy Forbeck Research Foundation Scholar.
　　

讲座摘要/Abstract:
　　MicroRNAs (miRNAs) are post-transcriptional regulators that play critical roles in diverse biological processes. Despite much research on the functions of miRNAs, a number of outstanding questions remain poorly answered. It is well known that mature miRNAs have distinctive expression patterns in different tissues and are often deregulated in disease conditions such as cancer. On the global level, which process is the main driver of miRNA gene expression and dysregulation? MiRNAs are produced initially as hairpin containing primary transcripts before being processed into mature miRNAs. However, many other RNAs in the cell can also form hairpins, but cannot enter the miRNA processing pathway. What are the qualitative and quantitative principles that govern the licensing of miRNA primary transcripts for processing? Once produced, mature miRNAs suppress target messenger RNAs through base-pairing involving the seed region of miRNA. However, computationally predicted target genes with similar target site features are often regulated by miRNA at vastly different levels. Are there missing rules that govern miRNA-mediated gene regulation? This talk will address these three questions.
　　

讲座联系人/Contact:
　　生命科学学院 学院办公室
　　李盛琪 lishengqi@westlake.edu.cn