时间：2019年10月29日（周二） 上午10：00- 11：30
　　Time:Oct 29, 2019 （Tues.） 10:00-11:30 AM
　　地点：西湖大学云栖校区2号楼311会议室
　　Venue:Room 311, Building 2, Yunqi Campus
　　主持人:工学院PI 张科春博士
　　Host:Kechun Zhang Ph.D., PI of School of Engineering
　　Speaker/主讲嘉宾：

　　Yajun Yan Ph.D., Associate professor,
　　School of Chemical, Materials and Biomedical Engineering,
　　College of Engineering The University of Georgia
　　

主讲人简介/Biography:
　　Dr. Yajun Yan got his Bachelor's degree (1999) and Master's degree (2002) in Biochemical Engineering at Beijing University of Chemical Technology. In 2008, he got his Ph.D. degree at University of Buffalo, the State University of New York in the Department of Chemical and Biological Engineering. During this period, his research focus was metabolic engineering. From 2008 to 2010, he did his postdoctoral research at the University of California, Los Angeles with further training in metabolic engineering and synthetic biology. In 2010, Dr. Yan joined the University of Georgia as an assistant professor of Biochemical Engineering and was promoted to associate professor with tenure in 2015 and full professor in 2019. His current research focuses on developing enzymatic and microbial approaches for the production of pharmaceutically important compounds as well as renewable fuels and chemicals.
　　

讲座摘要/Abstract:
　　The synthetic capability of microbial systems holds great potential for green manufacturing. To fully unlock the potential, expanding the product spectrum and enhancing the biosynthesis efficiency are highly desired, which call for the efforts in both construction of synthetic pathways for compounds beyond the confines of natural hosts and development of overproducing strains. Such efforts require not only discovering new enzymes or developing novel enzymatic activities to function in non-natural pathways but also reprograming cellular metabolism and regulation to better fuel such biosynthetic activities. In this seminar, selected projects will be presented to demonstrate our understanding and experience in these areas, which include: 1) rediscovering and engineering enzymes for novel functionalities based upon their catalytic mechanisms and molecular structures to realize microbial synthesis of various compounds ranging from renewable chemicals to natural products; 2) establishing synergetic carbon utilization mechanism and developing bifunctional dynamic control of cellular metabolism for production improvement in microbial hosts.
　　

讲座联系人/Contact：
　　工学院 张科春实验室
　　聂梦真 niemengzhen@westlake.edu.cn