时间：2020年10月30日（周五）下午16:00-17:30

Time：4:00-5:30 PM, Friday, Oct 30, 2020

地点：西湖大学云栖校区5号楼一楼学术报告厅

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus

主持人: 西湖大学生命科学学院院长 于洪涛教授

Host: Hongtao Yu, Chair Professor and Dean of School of Life Sciences, Westlake University

主讲人/Speaker：中科院院士,北京生命科学研究所资深研究员、科研副所长 邵峰教授

Prof. Feng Shao, Academician of Chinese Academy of Sciences, Investigator and Deputy Director for Academic Affairs, NIBS, Beijing, China

Dr. Feng Shao’s laboratory is interested in studying molecular mechanisms of bacterial infection and host innate immunity defense. Bacterial pathogens use specialized secretion systems such as type III/IV secretion system to inject effector proteins into host cells, serving as a key and universal virulence mechanism. The effectors usually harbor a unique and potent activity that modulates the function of key signaling molecules in the host, and this plays a critical role in bacterial survival and systemic infections. Using pathogens such as Shigella, Salmonella, Enteropathogenic E. coli (EPEC), Legionella and Burkholderia as the model, we are working to discover and reveal some novel and common biochemical mechanisms utilized by bacterial effectors in modulating host signal transduction pathways. However, little is known about how the inflammasome is assembled/activated, and the signaling cascade upstream of the inflammasome remains obscure. They are combining multiple approaches including biochemical reconstitution, cell biology and mouse genetics to identify new components in pathogen-induced inflammasome activation and to further reveal the underlying biochemical mechanism.

报告题目/Title:

Pyroptosis, Inflammation and Antitumor Immunity

讲座联系人/Contact:

科技合作部 毕老师

biguanying@westlake.edu.cn