时间：2021年12月09日（周四）下午16:00-17:30

Time：16:00-17:30, Thursday, Dec 9^th, 2021

主持人: 西湖大学理学院PI 王兆彬 博士

Host: Dr. Zhaobin Wang, PI of School of Science, Westlake University

地址：西湖大学云栖校区5号楼一楼学术报告厅

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus, Westlake University

张万斌 教授

上海交通大学化学化工学院、药学院

Prof. Wanbin Zhang

 School of Chemistry and Chemical Engineering; School of Pharmacy,

Shanghai Jiao Tong University

E-mail: wanbin@sjtu.edu.cn

主讲人/Speaker：

张万斌教授分别于1985年和1988年获华东理工大学学士和硕士学位，于1997年获日本大阪大学博士学位。1988年至1993年在华东理工大学任助教和讲师，1997年至2001年在大阪大学任助理教授，2001年至2003年在三菱化学横滨综合研究所任主任研究员。2003年起先后任上海交通大学教授、特聘教授和讲席教授，2017年起任上海市手性药物分子工程重点实验室主任。

Professor Wanbin Zhang received his BS and MS degrees from East China University of Science and Technology (ECUST) in 1985 and 1988 respectively. From 1993 to 1997, he undertook PhD studies at Osaka University under the supervision of Professor Isao Ikeda. He then worked as an assistant professor at Osaka University until 2001 and then as a research fellow at the Specialty Chemicals Research Centre of the Mitsubishi Chemical Corporation. Since 2003, he has worked as a professor in the School of Chemistry and Chemical Engineering at Shanghai Jiao Tong University (SJTU). In 2013, he was promoted to the position of distinguished professor. Professor Zhang's current research interests include organometallic chemistry, asymmetric catalysis, and pharmaceutical process chemistry.

讲座摘要/Abstract:

张万斌教授长期以来围绕手性分子精准构建和高效合成这一关键科学问题，在新型手性催化剂和高效不对称催化反应新体系的创制方面开展了系统性的研究工作，本次讲座将从以下三个方面给大家做一个总结汇报：

1）基于催化剂分子骨架的角度调控策略，创制了结构独特的中心手性、轴手性和面手性等三类催化剂，并将其应用于多例高效不对称催化反应，实现了抗病毒药物瑞德西韦等手性药物的高效合成；

2）基于双手性金属协同和弱作用力辅助等协同促进策略以提升催化效能，发展了双手性中心化合物立体发散性合成和丰产金属不对称催化氢化等高效不对称催化反应新体系，解决了这些反应的活性和选择性精准调控难题；

3）基于在手性催化剂和不对称催化反应方面的研究成果，开发出不对称催化氢化和氧化等关键技术，解决了青蒿素、薄荷醇等重要手性化合物的产业化合成瓶颈问题，并完成技术转让，相关企业已实现500升反应器规模的青蒿素中试合成和年产1000吨薄荷醇的规模化生产。

Professor Wanbin Zhang has been focusing on the key scientific problem of precise construction and efficient synthesis of chiral molecules and carried out systematic research work on the development of new chiral catalysts and novel catalytic asymmetric systems. This lecture will focus on the following three aspects:

1) Based on the angular control strategy of the catalyst framework, three types of catalysts with unique structures, such as central chirality, axial chirality and planar chirality, were synthesized and successfully applied to many efficient catalytic asymmetric reactions, including the asymmetric synthesis of the antiviral drug Remdesivir.

2) Based on the synergistic catalysis strategy of bimetallic corporation and weak bond interaction, new catalytic systems for stereodivergent synthesis and asymmetric hydrogenation with earth-abundant metal catalyst were developed to realize the precise control of the reactivity and selectivity.

3) Based on the achievements in chiral catalyst design and reaction methodology development, key asymmetric hydrogenation and oxidation technologies were developed to solve the bottleneck problem in the industrial synthesis of important chiral compounds such as artemisinin and menthol.

讲座联系人/Contact:

理学院，王旭，邮箱：wangxu@westlake.edu.cn

School of Science, Xu Wang, Email: wangxu@westlake.edu.cn