时间：9月13日星期二16:00-17:30    

Time：4:00-5:30 PM，Tues., Sept. 13th，2022

主持人：西湖大学生命科学学院特聘研究员 申恩志

    Host：Dr. En-Zhi Shen, PI of School of Life Sciences

地点：云谷校区E10-222（线下），云栖校区3号楼312会议室（线上）

Venue：E10-222, Yungu Compus （Onsite）; Room 312, Building 3, Yunqi Compus (Online)

主讲嘉宾/Speaker:

 Dr. Shouhong   Guang, School of Life Sciences, University of Science & Technology of China　　

Shouhong Guang is a chair professor at the University of Science and Technology of China (USTC). He graduated from USTC with bachelor and master degrees and then a Ph.D. degree from the University of Wisconsin-Madison with Professor Janet Mertz. He did his postdoc training with Professor Scott Kennedy and came back to USTC to set up his own lab in 2010. His research has been focusing on the mechanism and function of small regulatory RNAs in C. elegans and has discovered the nuclear RNAi defective pathway, a new class of antisense ribosomal siRNAs and nucleolar RNAi, and the protein machineries for piRNA transcription and processing. Meanwhile, he investigated the mechanism of transgenerational inheritance of RNAi. 

讲座摘要/Abstract:

The mechanistic underpinnings of RNAi are broadly conserved across eukaryotes. Initial successes utilizing small RNAs to target oncogenic and viral mRNAs have generated excitement that small RNAs may eventually be utilized to treat human diseases. Prior to the rational use of small RNAs in therapeutics, it is essential to understand their biogenesis, specificity, transportation, and endogenous roles.

Our lab is very interested in how small RNAs are generated, transported and regulated, and how they function in the nucleus in metazoan, especially in the model organism C. elegans. To address these questions, our lab applied forward and reverse genetics, in addition to proteomic approaches, to identify factors required for nuclear and nucleolar RNAi, and the biogenesis of small regulatory RNAs. We have discovered the nuclear RNAi defective (NRDE) pathway, a class of antisense ribosomal siRNAs (risiRNAs) and nucleolar RNAi, the protein machineries for piRNA transcription and processing (USTC complex, UAD-2, PICS complex). Meanwhile, we found that both nuclear and cytoplasmic machineries are required for transgenerational inheritance of RNAi.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn