新闻与活动 活动信息

CELLS第三期 | Changliang Liu刘长亮: Decoding Dopamine Signaling in the Brain

时间

2023年1月10日(周二)
上午10:30-12:00

地点

线上:腾讯会议 443-364-046

主持

西湖大学工学院 讲席教授 Mohamad Sawan

受众

全体师生

分类

学术与研究

CELLS第三期 | Changliang Liu刘长亮: Decoding Dopamine Signaling in the Brain

时间:2023年1月10日(周上午10:30-12:00

Time: 10:30am-12:00pm, Tuesday, January 10, 2023

线上腾讯会议 443-364-046

Online: Tencent Meeting 443-364-046

主持人: 西湖大学工学院 讲席教授 Mohamad Sawan

Host: Chair Professor of School of Engineering,  Westlake University

语言:英文

Language: English

主讲嘉宾/Speaker:

Dr. Changliang Liu刘长亮

Assistant Professor

School of Life Science

Westlake University

主讲人简介/Biography:

Dr. Changliang Liu received his B.S. from China Pharmaceutical University, Ph.D. from the Chinese Academy of Sciences, and postdoctoral  training in Pascal Kaeser’s lab at Harvard Medical School. His work has  identified new mechanisms of dopamine release and redefined the spatiotemporal principles of dopamine signaling. He is now an assistant professor at Westlake University, focusing on the biophysics of neurotransmission, striatal computation, motor control, and next-generation drug discovery.

讲座摘要/Abstract:

Despite the well-recognized importance of dopamine in a range of brain functions, the biophysical nature of dopamine signaling remains elusive. Here, I will discuss how dopamine release is organized and regulated in axons and how these features shape our current theory of neuromodulation. I will first show that the dopamine system is endowed with a micro-scale architecture for transmission, where dopamine release only happens at sparsely distributed hot spots in axons with extremely high speed and efficiency. I will then demonstrate that action potentials can be initiated in distal dopamine axons, which bypasses Cajal's law of dynamic polarization (dendrites-soma-axon information flow), serves as a physiological regulation for striatal functions, and contributes to behavior. These findings will build the foundation for understanding dopamine signaling in the brain and ultimately power the development of new therapeutic strategies for related disorders.

讲座联系人/Contact:

章倚天Yitian(Claire) Zhang

zhangyitian@westlake.edu.cn