时间：4月21日星期五16:00-17:30

Time：4:00-5:30 PM，Friday, Apr. 21st，2023

主持人：西湖大学生命科学学院特聘研究员 杨培国

    Host：Dr. Peiguo Yang, PI of School of Life Sciences

    地点：云谷校区E9-109

    Venue：E9-109，Yungu Campus

主讲嘉宾/Speaker:

Ge Bai, Principal Investigator, School of Brain Science and Brain Medicine, Zhejiang University

Dr. Ge Bai, School of Brain Science and Brain Medicine, Zhejiang University. He received his Ph.D. degree from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. He then did postdoctoral training at Salk Institute /HHMI. In 2017, he joined Zhejiang University. The current research of his laboratory is focused on motor-sensory circuit development and disease. His research has been published in Cell (2023, 2011), Nature (2015), Neuron (2011), Dev Cell (2007), etc. He has been awarded the first prize of Shanghai Natural Science, funded by the Original Exploration Project of NSFC and National Talent Project.

讲座摘要/Abstract:

Complex disease often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecular links remain elusive. Recently, we found that, upon environmental stress, many CMT2-causing mutant proteins adopt similar properties by entering stress granules (SGs), where they aberrantly interact with G3BP and integrate into SG pathways (Cui et. al. 2023 Cell). For example, glycyl-tRNA synthetase (GlyRS) is translocated from the cytoplasm into SGs upon stress, where the mutant GlyRS perturbs the G3BP-centric SG network by aberrantly binding to G3BP. This disrupts SG-mediated stress responses, leading to increased stress vulnerability in motoneurons. Disrupting this aberrant interaction rescues SG abnormalities and alleviates motor deficits in CMT2D mice. These findings reveal a stress-dependent molecular link across diverse CMT2 mutants, and provide a conceptual framework for understanding genetic heterogeneity in light of environmental stress.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn