时间：2023年8月22日（周二）16:00-17:30 

Time：4:00-5:30 PM, Tuesday, August 22, 2023

地点：西湖大学云谷校区 E9-109教室

Venue: E9-109, Yungu Campus

主持人：西湖大学生命科学学院 讲席教授付向东

Host: Chair Professor Xiang-Dong Fu, School of Life Sciences

主讲人/Speaker：

Vivek Malhotra

Chair and ICREA Professor Cell Biology

Center for Genomic Regulation, Spain

报告题目/Title:

TANGO1 for Collagen Secretion and A Means to Target Tissue Scarring

讲座摘要/Abstract:

How cells assemble the glue or the extracellular matrix (ECM) that binds cells to form skin, tissues of the specific form, and bones. In order to address these lofty objectives, we first need to understand the mechanism by which cells secrete ECM components like the collagens. The problem is that they are too bulky for secretion by the conventional vesicular transport pathway. Our discovery of TANGO1, a ubiquitously expressed, endoplasmic reticulum (ER) exit site resident, transmembrane protein has made the pathway of collagen secretion amenable to molecular analyses. Surprisingly, the export of collagens is not by vesicles but instead by transient tunnels. This allows rapid transport of collagen from the lumen of ER to the next compartment of the secretory pathway. TANGO1 is genetically mutated in patients with collagenopathies and we can now target TANGO1 to control collagen hyper secretion dependent scarring and tissue fibrosis. Our findings are helping in understanding the mechanism by which cells secrete the right quantity and quality of ECM components to make tissues and bones.

讲座联系人/Contact:

科技合作部Sci-tech02@westlake.edu.cn