时间：2023年8月21日（周一）c

Time: 9:30am-10:30am, Monday, August 21, 2023

地点：西湖大学云谷校区E10-205

Venue: E10-205, Yungu Campus

主持人: 西湖大学工学院 张越 博士

Host: Dr. Yue Zhang, Assistant Professor, Westlake University

语言：英文

Language: English

主讲嘉宾/Speaker：

Dr. Xiaohua Qin

Principal Investigator, Group Leader

Institute for Biomechanics

ETH Zurich

主讲人简介/Biography:

Dr. Xiao-Hua Qin is a Principal Investigator in the Institute for Biomechanics (IfB) at ETH Zurich. He is currently leading a multidisciplinary group “Micro-Tissue Engineering and Biomaterials” with 3 postdocs and 6 PhDs to create 4D biomaterials for regenerative medicine. He received a Ph.D. degree (2014) with distinction in Polymer Chemistry at Vienna University of Technology where he co-invented thiol-ene photo-clickable hydrogels for fast two-photon direct laser writing. After 2 years training at the Ludwig Boltzmann Institute for Clinical Traumatology, he relocated to the Swiss Federal Institute for Materials Science (EMPA) in 2015 as a Marie-Curie Postdoc Fellow. There he explored cutting-edge organoid engineering and micro-robotics. In 2018 he joined the IfB at ETH Zurich and was promoted in 2019. He is the recipient of ETH Zurich Career Seed Award (2018), Swiss National Science Foundation Spark Award (2019), and a prestigious European Research Commission (ERC) Starting grant (2023).

讲座摘要/Abstract:

The natural extracellular matrix (ECM) represents a complex and dynamic environment. It provides numerous spatio‐temporal signals mediating many cellular functions including morphogenesis, adhesion, proliferation and differentiation. The cell–ECM interaction is bidirectional. Cells dynamically receive and process information from the ECM and remodel it at the same time. These complex interactions are still not fully understood. For better understanding, it is indispensable to deconstruct the ECM up to the point of investigating isolated characteristics and cell responses to biophysical and chemical cues.  In this seminar, I will present our efforts in developing photoresponsive hydrogels for 4D bioengineering. Specifically, I will highlight these examples: 1) designing a modular, photo-clickable, matrix metalloproteinase (MMP)-sensitive PVA hydrogel for 4D tissue and organoid engineering; 2) applying a dynamic photoresin for volumetric bioprinting of permissive hydrogel constructs within 5-20 seconds; and 3) establishing subtractive two-photon hydrogel patterning for laser-guided formation of 3D cellular networks at (sub)micron-scale resolution.

讲座联系人/Contact:

乐佳清

lejiaqing@westlake.edu.cn