时间：10月10日星期二16:00-17:30

Time：4:00-5:30 PM，Tuesday, October 10，2023

主持人：西湖大学生命科学学院讲席教授 裴端卿

    Host：Dr. Duanqing Pei, Chair Professor, School of Life Sciences

    地点：云谷校区E9-109

    Venue：E9-109, Yungu Campus

主讲嘉宾/Speaker:

Di Chen, Tenure-track Associate Professor, Principal Investigator, Zhejiang University-University of Edinburgh Institute, Zhejiang University

Dr. Di Chen obtained his BSc in Marine Biology from the Ocean University of China in 1997, and Ph.D. in Genetics from the University of Missouri-Columbia, USA in 2004. He was supervised by Dr. Donald L. Riddle to study the developmental diapause of the nematode C. elegans. He then did post-doctoral training in Dr. Pankaj Kapahi’s lab at the Buck Institute for Research on Aging, USA, where he studied the molecular mechanisms of aging. He worked at the Model Animal Research Center, Nanjing University as a Principal Investigator from 2013 to 2023. He has recently joined the Zhejiang University-University of Edinburgh Institute as a tenured Associate Professor. Dr. Chen's research group focuses on understanding the molecular basis of aging and age-related pathologies.

讲座摘要/Abstract:

Aging can be modulated by genetic and environmental factors. Inhibition of the highly conserved insulin/IGF-1 signaling (IIS) or target of rapamycin (TOR) pathway significantly delays aging. However, it has not been clear how these pathways interact with each other to affect aging, especially from the tissue-specific point of view. My group previously demonstrated that double mutations in DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) result in a nearly 5-fold, super longevity phenotype in C. elegans. I will present our findings on the molecular mechanisms of this super longevity that involves tissue-specific regulation of highly conserved genes and cell-non-autonomous activation of the mitochondrial stress response.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn