时间：10月18日星期三10:00-11:30

Time：10:00-11:30 AM，Wednesday, October 18，2023

主持人：西湖大学生命科学学院讲席教授 裴端卿

    Host：Dr. Duanqing Pei, Chair Professor, School of Life Sciences

    地点：云谷校区E10-215

    Venue：E10-215, Yungu Campus

主讲嘉宾/Speaker:

Dr. Ge Guo, Principal Investigator, Living Systems Institute, University of Exeter

Dr Ge Guo is a stem cell biologist.  She obtained her PhD at the University of Cambridge with Prof. Allan Bradley.  During her PhD, she developed approaches for recessive genetic screens using mouse embryonic stem cells. In 2006 she joined Prof. Austin Smith's laboratory and was awarded an MRC stem cell career development fellowship to investigate novel genes regulating mouse pluripotency. She then became intrigued by the difference between mouse and human pluripotent stem cell states and redirected her research towards human naïve pluripotency.  She is one of the pioneers in the establishment and characterization of human naïve pluripotent stem cells.  In 2020, Ge joined the Living Systems Institute, University of Exeter, as a Principal Investigator. In her recent research, Ge discovered the trophectoderm differentiation potential of human naïve pluripotent stem cells, which led to the establishment of integrated human embryo models.  Her current research is centred on understanding the regulatory mechanism of pluripotency and cell fate transition during early embryogenesis.

讲座摘要/Abstract:

Understanding how cell fates are specified and spatially organised to form a human embryo is a fascinating fundamental biology question. Studying human embryogenesis is inherently challenging, and significant efforts have been made to develop alternative stem cell-based models. We have established human naïve pluripotent stem cells (PSCs), which resemble the naïve epiblast in the blastocyst. These human naïve PSCs retain extraembryonic lineage potency, and they can self-organize into blastoids that closely resemble blastocysts in cellular composition, topology, and regulation of lineage specification. Therefore, human naïve PSCs and the derivative blastocyst model provide a valuable experimental system to study cell fate specification in early embryogenesis. In this talk, I will discuss our current research aimed at understanding the regulatory mechanism of the sequential trophectoderm and hypoblast lineage specification in human naïve PSCs, blastoids, and natural embryos.

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn