时间：2024年9月30日（周一） 11:00-12:00

Time: 11:00-12:00, Monday, September 30, 2024

地点：西湖大学云谷校区 E1-314

Venue: E1-314, Yungu Campus

主持人: 西湖大学工学院 曾安平 讲席教授

Host: Prof. An-ping Zeng, Chair Professor, Westlake University

语言：英文

Language: English

主讲嘉宾/Speaker：

Prof. Fei Wen

Associate Professor

The  University of Michigan

主讲人简介/Biography:

Fei Wen received her Ph.D. degree in Chemical Engineering from the University of Illinois at Urbana Champaign (UIUC) in 2010, and her B.S. degree in Chemical Engineering from Tsinghua University in 2003. She joined the faculty at the University of Michigan in 2012 after completing her postdoc training in Microbiology & Immunology at Stanford. She is currently the Associate Department Chair for Undergraduate Education, the founder and Director of the UM CyTOF Facility, and the Co-Director of Immune Monitoring Shared Resources at the UM Rogel Cancer Center. Her research focuses on understanding and engineering complex biological systems using quantitative single-cell analytic approaches. She has published 40 papers, 5 book chapters, and 4 patents with an average of 450 citations per year in the past three years. She has received many awards in recognition of her contributions in research, teaching, and service including the Dow Corning Assistant Professorship, UM Provost’s Teaching Innovation Prize, NSF CAREER Award, and UIUC Young Alumni Achievement Award.

讲座摘要/Abstract:

As the most abundant renewable carbon source on Earth, lignocellulosic biomass represents a promising, low-cost feedstock for biofuel production. In recent years, the use of yeasts as whole-cell biocatalysts for lignocellulosic conversion has garnered significant research interest due to their generally regarded as safe (GRAS) status, easy gene manipulation, and high alcohol tolerance. However, the yeast whole-cell biocatalysts (yWCBs) available today cannot efficiently break down lignocellulose and ferment the hydrolysates. In this work, we developed quantitative methods to guide the optimization of yeast as a biosynthetic host and applied these methods to tackle challenges impeding the valorization of lignocellulose. These methods not only accelerate the development of yeast as a biosynthetic host for biofuel production, but are also broadly applicable for engineering microbes to enhance their biomanufacturing potential in the chemical, therapeutic, and vaccine industries.

讲座联系人/Contact:

huangyuhui@westlake.edu.cn