时间：10月31日星期四16:00-17:30

Time：4:00-5:30 PM, Thursday, October 31，2024

主持人：西湖大学生命科学学院讲席教授 许田

    Host：Dr. Tian Xu, Chair Professor, School of Life Sciences

    地点：云谷校区E9-109会议室

    Venue：Room E9-109, Yungu Campus  

主讲嘉宾/Speaker:

Dr. Xin Sun, Professor, Department of Pediatrics, University of California-San Diego; Founding Director of UCSD Lung Center

My research focuses on elucidating the genetic, genomic and epigenomic mechanisms of lung stem cell function in development, regeneration, repair and disease. My early work contributed to the fundamental understanding of developmental processes including limb patterning and gastrulation. In our current focus on lung, my lab has investigated the function of a broad spectrum of factors, including signals and receptors (FGFs, WNTs, HHs, BMPs, SLIT and their corresponding receptors), cytoplasmic effectors (Dicer, microRNAs, E3 ubiquitin ligases, myosin light chain kinase and LONP1), and transcription factors (NKX2-1, SOX2, ASCL1, Myocardin, ETVs and MYRF) in lung development and disease. The array of lung diseases that we have studied include rare disorders such as congenital diaphragmatic hernia (abdominal organs in chest preventing respiration), neuroendocrine cell hyperplasia of infancy (increased neuroendocrine cells and respiratory deficiency), tracheobronchomalacia (floppy trachea and bronchi) and tracheoesophageal fistula (persistent connection between trachea and esophagus).  We have also studied more prevalent diseases such as bronchopulmonary dysplasia, pulmonary fibrosis, COPD, asthma and respiratory infection induced lung injury. We use CRISPR/Cas9 genome editing to generate genetic mouse models to study human disease mechanisms. As part of the NIH LungMAP and HuBMAP consortia, we use advanced technologies to profile single cell transcriptomic and epigenomic signatures of the human lung. Extending from our work on pulmonary neuroendocrine cells, a critical sensor in the lung, we study neural circuit control of lung function. I have also applied my expertise in mouse genetics into teaching, including serving as Director of the flagship Cold Spring Harbor Mouse Development, Stem Cell and Cancer summer course. 

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn