时间：2025年5月6日（周二） 上午10:00~11:30

Time：10:00~11:30 PM, Tuesday, May 6th, 2025

地点：西湖大学云栖校区5号楼一楼报告厅

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus

主持人：西湖大学生命科学学院特聘研究员 申怀宗

Host: Dr. Huaizong Shen, Principal Investigator, School of Life Sciences

主讲人/Speaker：

Yifan Cheng

Investigator of Howard Hughes Medical Institute 

Professor at Department of Biochemistry and Biophysics, University of California San Francisco

报告题目/Title:

Conformational dynamics drives integrin avb8 mediate L-TGF-b activation

讲座摘要/Abstract:

In the era of single particle cryo-EM and AI driven protein structure prediction, determining high-resolution structure is no longer a difficult but an achievable goal. However, study and understand protein dynamics is still a challenging task. Using avb8 mediated L-TGF-b1 activation as an example, I intend to illustrate the significance and challenging of studying protein dynamics, when conformational dynamic is part of protein function. TGF-b, essential for development and immunity, is expressed as a latent complex (L-TGF-b) non-covalently associated with its prodomain and presented on immune cell surfaces by covalent association with GARP. Binding to integrin avb8 activates L-TGF-b1/GARP. The dogma is that mature TGF-b must physically dissociate from L-TGF-b1 for signaling to occur. Our previous studies discovered that avb8-mediated TGF-b autocrine signaling can occur without TGF-b1 release from its latent form. We reveal a dynamic allosteric mechanism of autocrine TGF-b1 signaling without release where avb8 binding redistributes the intrinsic flexibility of L-TGF-b1 to expose TGF-b1 to its receptors. 

讲座联系人/Contact:

科技合作部 Sci-tech02@westlake.edu.cn