时间：2025年4月29日（周二）10:30-12:00

Time: 10:30-12:00, Tuesday, April 29, 2025

地点：西湖大学云谷校区E10-211

Venue：E10-211, Yungu Campus

主持人: 西湖大学工学院讲席教授 Mohamad Sawan

Host: Mohamad Sawan, Chair Professor of School of Engineering, Westlake University

主讲嘉宾/Speaker：

陈颉教授

复旦大学生物医学工程与技术创新学院院长

主讲人简介/Biography:

Chen Jie, Ph.D., is a Fellow of the Canadian Academy of Engineering, a Fellow of the Institute of Electrical and Electronics Engineers (IEEE Fellow), a Fellow of the American Institute for Medical and Biological Engineering, and a Fellow of the Asia-Pacific Artificial Intelligence Association. He currently serves as the Founding Dean of the School of Biomedical Engineering at Fudan University. His research areas include microfluidic in vitro diagnostic chips, organ-neural chips, biomedical integrated circuits and wearable devices, and AI-based mental health diagnosis and therapy. He has published 3 books and 263 papers in top international journals (PNAS, ACS Nano, Physical Review Letters, Small, Nature Microsystems & Nanoengineering, Nature npj Mental Health) and leading IEEE journals (Proceedings of the IEEE, IEEE Journal on Solid-State Circuits, IEEE Transactions on Circuits and Systems, IEEE Transactions on Biomedical Engineering, and IEEE Transactions on Biomedical Circuits and Systems) as well as in major international conferences. His research has been cited over 9,630 times, with an h-index of 48. He helped found two Bell Labs spin-off companies. One of them, Flarion Technologies Inc., focused on developing 4G wireless networks and was later acquired by QUALCOMM (San Diego, USA). The other company, iBiquity Digital, specialized in HD Radios, which are now widely used in BMW, General Motors, Ford, Toyota, and Honda vehicles and are available in major retail chains such as Walmart and Best Buy. In 2015, iBiquity Digital was acquired by DTS (California, USA).

讲座摘要/Abstract:

With the advancement of microfluidic and organoid technologies, neuron-on-a-chip platforms have demonstrated tremendous potential in precisely replicating the three-dimensional structure of the brain, simulating intercellular interactions, and reconstructing in vitro physiological models. On one hand, compared to traditional two-dimensional cell cultures, neuron-on-a-chip systems can not only construct more complex physiological architectures but also provide a dynamically controllable developmental environment for neural tissues. On the other hand, compared to animal models, brain-on-a-chip technology not only effectively addresses the limitations in the number of available animal models, but also alleviates, to some extent, the ethical concerns associated with animal experiments. Through induced pluripotent stem cell (iPSC) technology, we can directly model human brain pathological phenotypes on chips, overcoming challenges posed by interspecies differences in animal models, and enabling the investigation of key events in the progression of human neurological disorders. In addition, neuron-on-a-chip systems can be integrated with other organoid tissues on microfluidic chips to create multi-organ-on-a-chip platforms. Compared to single-organ chips, multi-organ systems can reconstruct multiple human tissue organoids in vitro, enabling precise simulation of inter-organ interactions.

讲座联系人/Contact:

Fangyuan(Tiffany) Tian

tianfangyuan@westlake.edu.cn