时间：3月30日 ,16:00-17:30

Time：4:00-5:30 PM，Tue.，Mar 30, 2021

地点：西湖大学云栖校区5号楼学术报告厅

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus

主持人：西湖大学生命科学学院 俞晓春教授

Host：Prof. Xiaochun Yu, School of Life Sciences, Westlake University

主讲嘉宾/Speaker:

Jun Huang Ph.D.

Professor and Vice-director of the Life Sciences Institute, Zhejiang University

主讲人/Speaker：

Dr. Huang received his B.S. degree from Nankai University in 2001, and Ph.D. degree from Peking University in 2006. He then did his postdoctoral training at Yale University and MD Anderson Cancer Center from 2006 to 2010. Dr. Huang started his own laboratory at Zhejiang University in January 2010. He is now the Professor and Vice-director of the Life Sciences Institute, Zhejiang University. His research mainly focuses on understanding the molecular mechanisms underlying genome instability and tumorigenesis. He was awarded “National Program for Special Support of Eminent Professionals” and “Young and Middle-aged Leading Talents in Scientific and Technical”. In 2013 he acquired the “National Natural Science Funds for Distinguished Young Scholars”. He published more than 40 peer-reviewed papers in leading scientific journals like Science、Mol Cell、Nat Commun.、Proc Natl Acad Sci U S A、Curr Biol.、J Cell Biol.、EMBO Rep.、and Cell Rep.

讲座摘要/Abstract:

During genome replication, replication forks often encounter obstacles that impede their progression. Arrested forks are unstable structures that can give rise to collapse and rearrange if they are not properly processed and restarted. Replication fork reversal is a critical protective mechanism in higher eukaryotic cells in response to replication stress, in which forks reverse their direction to form a Holliday junction-like structure. The reversed replication forks are protected from nuclease degradation by DNA damage repair proteins, such as BRCA1, BRCA2 and RAD51. Some of these molecules work cooperatively, while others have unique functions. Once the stress is resolved, the replication forks can restart with the help of enzymes, including human RECQ1 helicase. I will discuss the impact of fork reversal on the integrity of replicating chromosomes.

讲座联系人/Contact:

生命科学学院

于文越 yuwenyue@westlake.edu.cn