时间：11月12日星期二16:00-17:30

Time：4:00-5:30 PM, Tuesday, November 12，2024

主持人：西湖大学生命科学学院特聘研究员 蒋敏

    Host：Dr. Min Jiang, Principal Investigator, School of Life Sciences

    地点：云谷校区E9-109会议室

    Venue：Room E9-109, Yungu Campus

主讲嘉宾/Speaker:

Dr. Hong Xu, Senior Investigator, The National Institutes of Health (NIH) 

Hong Xu graduated from Nankai University with a B.S. in 1995 and received a M.S. from Peking University in 1998. He earned his Ph.D. in 2004 from the Johns Hopkins University School of Medicine, where he worked with Craig Montell. Dr. Xu did his postdoctoral fellowship at the University of California, San Francisco with Patrick O’Farrell, during which time he pioneered a new line of study, mtDNA genetics and inheritance in Drosophila. Dr. Xu joined NIH a tenure-track Investigator in 2010 and was promoted to senior investigator in 2017.

讲座摘要/Abstract:

The limitation of Mendelian genetics to explain many complex traits has prompted attention outside the nucleus. In addition to the nuclear genome, eukaryotic lives have a second genome, mitochondrial DNA (mtDNA) that codes proteins essential for energy metabolism. Mutations on mtDNA have emerged as important factors compromising human health and shaping the eukaryotes evolution. Different from the nuclear genome, mtDNA is transmitted through the maternal linage exclusively. Over the years, my lab has been developing various Drosophila models and using these models to study the basic principles guiding the transmission of mtDNA. I will talk about the developmental, cellular and molecular mechanisms that limit the transmission of deleterious mtDNA mutations during oogenesis. I will also introduce a new line of study in the lab, aiming to understand evolution pressure favoring uniparental inheritance of the mitochondrial genome. 

联系人/Contact：

生命科学学院

于文越 yuwenyue@westlake.edu.cn