Time：16:00-17:30, Monday, June 26th, 2023

Host: Prof. Hongfei Wang, PI of School of Science, Westlake University

Venue: E10-201,Yungu Campus, Westlake University

Prof. Feng Gai,

Chair Professor of Peking University

E-mail: fgai@pku.edu.cn

主讲人/Speaker：

盖锋，北京大学讲席教授、北京大学化学与分子工程学院李革赵宁讲席教授、北京大学化学与分子工程学院整合谱学中心主任、博士生导师，美国科学促进会会士，美国物理学会会士，1994年在爱荷华州立大学化学系获得博士学位，1994-1999先后在哈佛大学化学系和洛斯阿拉莫斯国家实验室做博士后，1999-2021在宾夕法尼亚大学化学系任教，2014-2021任宾夕法尼亚大学化学系的Edmund J. and Louise W. Kahn Term Professor。获NSF CAREER Award和ACS Philadelphia Section Award。主要从事生物大分子的构象动力学研究，发展光谱探针和多维光谱技术。

讲座摘要/Abstract:

The folded structure of a protein is stabilized by several weak interactions and, as a result, it can undergo various local and global conformational fluctuations, and some of which may be required for function. In addition, a protein may sample a dynamic conformational ensemble without forming well-defined and long-lasting tertiary contacts, being intrinsically disordered. Therefore, in order to yield a microscopic understanding of the underlying conformational energy landscape as well as the structure-dynamics-function relationship of the protein in question, it is often necessary to acquire structural, dynamic, or other physical information at the individual amino acid level. However, it is not easy or even feasible to obtain such information via native spectroscopic signals, as they often lack the required structural and/or spatial resolutions. In this talk, we will discuss our ongoing effort to overcome this limitation. In particular, we will describe several examples, showing how nonnatural amino acid-based spectroscopic probes can be used to reveal, in a site-specific manner, protein electric field, solvent accessibility, conformation, conformational dynamics, among other applications.

Contact:

School of Science, Li Huang, Email: huangli10@westlake.edu.cn