时间：2024年9月5日（周四）下午16:00-17:30

Time：16:00-17:30, Thursday, September 5th, 2024

主持人: 西湖大学交叉科学中心副主任&讲席教授 汤雷翰博士

Host: Dr. Leihan Tang, Vice Director & Chair Professor of Center for Interdisciplinary Studies (CIS), Westlake University

地址：西湖大学云谷校区E10-222

Venue: E10-222, Yungu Campus, Westlake University

讲座语言：英文

Lecture Language: English

杜茁 研究员

中国科学院遗传与发育生物学研究所

Dr. Zhuo Du,

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

E-mail: zdu@genetics.ac.cn

主讲人/Speaker:

Dr. Du received his Ph.D. from China Agricultural University in 2008 and conducted postdoctoral research at Albert Einstein College of Medicine and Memorial Sloan Kettering Cancer Center from 2008 to 2014. His work focused on the systems biology of cell lineage and embryogenesis, using the nematode C. elegans as the model. In 2015, Dr. Du joined the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, as a group leader in the Center for Molecular Systems Biology. Dr. Du's lab is dedicated to unraveling the complexities of embryogenesis—the extraordinary process by which a single cell develops into a complete organism—through the lens of the C. elegans model. The team adopts a cell-centric approach to development, treating individual cells as functional and regulatory units, and leveraging systems biology strategies to decode the underlying regulatory mechanisms. Over the past five years, the lab's research has been published in journals including Nature Methods, Cell Systems, Molecular Systems Biology, Nature Communications, and Cell Reports.

讲座摘要/Abstract:

My lab is dedicated to unraveling the regulatory principles of embryogenesis through systems-level analyses using in situ, single-cell approaches. In this talk, I will first introduce our live imaging-based systematic approach to simultaneously trace the molecular activity and cellular functions of individual cells throughout embryogenesis, with C. elegans as our model organism. I will then present two of our recent studies that demonstrate how our approach enhances the systems-wide understanding of the complex processes underlying embryogenesis. In the first study, we performed single-cell imaging of protein expression for diverse transcription factors (TFs), which enabled us to reveal a TF patterning code of cell fates and general properties of cell state dynamics. In the second study, we conducted a single-cell phenomic analysis of embryogenesis following the perturbation of hundreds of conserved genes. This analysis revealed a cellular-level phenotypic compensation process that buffers the detrimental effects of genetically-induced cellular defects, thereby ensuring the robustness of embryogenesis. Together, I hope this talk will highlight the potential of live imaging in bridging molecular activity and cellular function, providing valuable insights into the regulation of complex multicellular processes.

讲座联系人/Contact:

交叉科学中心，朱子霖，邮箱：zhuzilin@westlake.edu.cn

Center for Interdisciplinary Studies (CIS), Ms. Zilin Zhu, Email: zhuzilin@westlake.edu.cn