时间：2022年9月16日（周五）14:00-15:30

Time：2:00-3:30 PM, Friday, Sept. 16, 2022

地点：西湖大学云栖校区学术报告厅

Venue: Lecture Hall, Building 5, Yunqi Campus

主持人：西湖大学生命科学学院讲席教授 施一公

Host: Dr. Yigong Shi, Chair Professor, School of Life Sciences

主讲人/Speaker：

Mingjie Zhang

Before becoming the Founding Dean of the School of Life Sciences, Southern University of Science and Technology (SUSTech) at the end of 2020, Prof Zhang was a Kerry Holdings Professor of Science, Senior Fellow of the Institute for Advanced Study, and Chair Professor in the Division of Life Science, HKUST. Research in Prof. Zhang’s laboratory has been focusing on molecular basis governing neuronal synapse formation and plasticity in the past 27 years. Their breakthrough discovery on phase separation-mediated synapse formation has far reaching implications in basic as well as translational research in neuroscience. More than 20 Ph.D. graduates and postdoctoral fellows trained in his lab have established their independent research groups around the world.

报告题目/Title:

Phase Separation in Synapse Formation and Function

讲座摘要/Abstract:

Emerging evidence indicates that liquid-liquid phase separation, the formation of a condensed molecular assembly within another diluted aqueous solution, is a means for cells to organize highly condensed biological assemblies with broad functions and regulatory properties in different subcellular regions. Molecular machineries dictating synaptic transmissions in both presynaptic boutons and postsynaptic densities of neuronal synapses are such biological condensates. In this talk, I will first summarize our recent work showing how phase separation can build dense synaptic molecular clusters, highlight unique features of such condensed clusters in the context of synapse formation and plasticity. Then, I will present some of our unpublished work showing how phase separation regulates various synaptic functions. I will try to illustrate that our observations of phase separation processes in neuronal synapses can be extended to many cellular events in general.

讲座联系人/Contact:

科技合作部 sci-tech02@westlake.edu.cn