时间：2023年4月6日（周四）上午10:00~11:30

Time：10:00-11:30 AM, Thursday, Apr. 6, 2023

地点：西湖大学云谷校区E10-222

Venue: E10-222, Yungu Campus

主持人：西湖大学生命科学学院讲席教授  于洪涛

Host: Dr. Hongtao Yu, Chair Professor, School of Life Sciences

主讲人/Speaker：

Wei Xie

School of Life Sciences, Tsinghua University

报告题目/Title:

Decoding the Transcription Circuitry When Life Begins

讲座摘要/Abstract:

Zygotic genome activation (ZGA) marks the first transcription event in development. Deciphering key regulators of ZGA is crucial for understanding how life begins and how a totipotent embryo arises from terminally differentiated gametes. Probing these questions in mammals was long hindered by the scarce experimental materials that are available from early embryos. By developing a set of ultra-sensitive chromatin analysis technologies, we previously investigated chromatin accessibility, epigenetic modifications, 3D chromatin architecture, and RNA Pol II engagement during mammalian ZGA. These studies unveiled highly dynamic and non-canonical transcription and chromatin regulation during the maternal-to-zygotic transition. However, how ZGA is kickstarted and how the early development program is progressively driven by transcription regulators remain enigmatic. Recently, we sought to identify transcription regulators that may act at the onset of ZGA by ultra-sensitive Ribo-seq. In this talk, I will discuss how these findings help illuminate the core transcription circuitry underlying the beginning of life. 

讲座联系人/Contact:

科技合作部 sci-tech02@westlake.edu.cn