时间：2023年10月20日（周五）16:00~17:30

Time：4:00-5:30 PM, Friday, October 20, 2023

地点：西湖大学云谷校区E10-201

Venue: E10-201, Yungu Campus

主持人：西湖大学理学院PI 王兆彬博士

Host: Dr. Zhaobin Wang, PI of School of Science

主讲人/Speaker：

Gregory C. Fu

Norman Chandler Professor of Chemistry

Department of Chemistry and Chemical Engineering

California Institute of Technology

Prof. Greg Fu received a B.S. degree in 1985 from MIT, where he worked in the laboratory of Prof. K. Barry Sharpless. After earning a Ph.D. from Harvard in 1991 under the guidance of Prof. David A. Evans, Prof. Fu spent two years as a postdoctoral fellow with Prof. Robert H. Grubbs at Caltech. In 1993, he returned to MIT, where he served as a member of the faculty from 1993–2012. In 2012, he was appointed the Altair Professor of Chemistry at Caltech. Prof. Fu is currently the Norman Chandler Professor of Chemistry at Caltech.The current research interests of the Fu laboratory include metal-catalyzed coupling reactions and the design of chiral catalysts. In particular, the group is focused on the development of nickel-catalyzed enantioselective cross-couplings of alkyl electrophiles and on photoinduced, copper-catalyzed carbon–heteroatom bond-forming reactions (collaboration with the laboratory of Prof. Jonas Peters).Prof. Fu received the Corey Award of the American Chemical Society (ACS) in 2004, the Mukaiyama Award of the Society of Synthetic Organic Chemistry of Japan (SSOCJ) in 2006, the Award for Creative Work in Synthetic Organic Chemistry of the ACS in 2012, the H. C. Brown Award of the ACS in 2018, and the Noyori Prize of the SSOCJ in 2022. He is a member of the American Academy of Arts and Sciences (2007) and of the National Academy of Sciences (2014).

报告题目/Title:

Nucleophilic Substitution Reactions: A Radical Alternative to SN1 and SN2 Reactions

讲座摘要/Abstract:

Classical methods for achieving nucleophilic substitutions of alkyl electrophiles (SN1 and SN2) have limited scope and are not generally amenable to enantioselective variants that employ readily available racemic electrophiles. In this presentation, I will describe how the combination of radical chemistry and transition-metal catalysis has opened the door to addressing the challenges of reactivity and of enantioselectivity in nucleophilic substitution reactions of secondary and tertiary alkyl electrophiles.

讲座联系人/Contact:

科技合作部Sci-tech02@westlake.edu.cn