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西湖名师论坛第215期 | Todd Hyster: Photoenzymatic Catalysis – Using Light to Reveal New Enzyme Functions
时间
2023年10月26日(周四)
16:00~17:30
地点
西湖大学云谷校区E10-201阶梯教室
主持
西湖大学理学院 叶宇轩教授
受众
全体师生
分类
学术与研究
西湖名师论坛第215期 | Todd Hyster: Photoenzymatic Catalysis – Using Light to Reveal New Enzyme Functions
时间:2023年10月26日(周四)16:00~17:30
Time:4:00~5:30 PM, Thursday, Oct. 26th, 2023
地点:西湖大学云谷校区E10-201阶梯教室
Venue: E10-201, Yungu Campus
主持人:西湖大学理学院 叶宇轩教授
Host: Prof. Yuxuan Ye, School of Science of Westlake University
主讲人/Speaker:
Todd Hyster
Professor of Chemistry at Princeton University
Prof. Todd Hyster is a Professor of Chemistry at Princeton University. He received his B.S. in Chemistry from the University of Minnesota. He did his Ph.D. studies with Tomislav Rovis at Colorado State University. As part of his Ph.D., he was a Marie Curie Fellow with Thomas Ward at the University of Basel. He was an NIH Postdoctoral Fellow with Prof. Frances Arnold at Caltech. He started his independent career at Princeton University in 2015. He joined the faculty at Cornell from 2021-2023 before returning to Princeton. His group is focused on developing new activation modes for enzymes.
报告题目/Title:
Photoenzymatic Catalysis – Using Light to Reveal New Enzyme Functions
讲座摘要/Abstract:
Enzymes are exquisite catalysts for chemical synthesis, capable of providing unparalleled levels of chemo-, regio-, diastereo- and enantioselectivity. Unfortunately, biocatalysts are often limited to the reactivity patterns found in nature. In this talk, I will share my group’s efforts to use light to expand the reactivity profile of enzymes. In our studies, we have exploited the photoexcited state of common biological cofactors, such as NADH and FMN to facilitate electron transfer to substrates bound within enzyme active sites. In other studies, we found that enzymes will electronically activate bound substrates for electron transfer. In the presence of common photoredox catalysts, this activation can be used to direct radical formation to enzyme active sites. Using these approaches, we can develop biocatalysts to solve long-standing selectivity challenges in chemical synthesis.
讲座联系人/Contact:
科技合作部Sci-tech02@westlake.edu.cn