时间：2023年10月26日（周四）16:00~17:30

Time：4:00-5:30 PM, Thursday, October 26, 2023

地点：西湖大学云谷校区E10-222

Venue: E10-222, Yungu Campus

主持人：西湖大学生命科学学院 讲席教授 于洪涛

Host: Dr. Hongtao Yu, Chair Professor and Dean, School of Life Sciences

主讲人/Speaker：

Don W. Cleveland

Professor and Chair of Cellular and Molecular Medicine at University of California San Diego

报告题目/Title:

Evolution of Genome Instability in Cancer

讲座摘要/Abstract:

Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. The most frequent type based on large-scale DNA sequencing of human tumors is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event. Chromothripsis can be initiated by mitotic errors that produce a micronucleus encapsulating a single chromosome or chromosomal fragment. Rupture of the unstable micronuclear envelope exposes its chromatin to cytosolic nucleases and induces chromothriptic shattering. Chromatin-bound tethers maintain proximity of fragments of a shattered chromosome enabling their re-encapsulation into, and religation within, a daughter cell nucleus to form heritable, chromothriptically rearranged chromosomes found in the majority of human cancers. Chromothriptic rearrangements contribute to tumorigenesis through inactivation of tumor suppressor genes, activation of proto-oncogenes, or gene amplification through production of self-propagating extrachromosomal circular DNAs (ecDNAs) encoding oncogenes or genes conferring anti-cancer drug resistance.

讲座联系人/Contact:

科技合作部Sci-tech02@westlake.edu.cn