时间：2023年11月10日（周五）上午10:00~11:30

Time：10:00~11:30 AM, Friday, November 10, 2023

地点：西湖大学云谷校区E10-222

Venue: E10-222, Yungu Campus

主持人：西湖大学生命科学学院 讲席教授 于洪涛

Host:  Dr. Hongtao Yu, Chair Professor, School of Life Sciences

主讲人/Speaker：

Zhijian ‘James’ Chen

Member of the National Academy of Sciences

Laureat of 2007 The Edith and Peter O'Donnell Awards, 

2019 Breakthrough Prize in Life Sciences

Professor in the department of molecular biology at University of Texas Southwestern Medical Center, George L. MacGregor Distinguished Chair in Biomedical Science, 

Investigator of the Howard Hughes Medical Institute

报告题目/Title:

DNA Immunity: From Human to Bacteria and Back

讲座摘要/Abstract:

Zhijian "James" Chen’s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body’s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupus. Treatment of these autoimmune diseases could involve chemical inhibition of cGAS, whereas cGAMP and its derivatives may be used as adjuvants for vaccines and cancer immunotherapies.

讲座联系人/Contact:

科技合作部Sci-tech02@westlake.edu.cn