时间：2025年9月23日（周二）14:00~16:00

Time：2:00~4:00 PM, Tuesday, Sep. 23rd, 2025

地点：西湖大学云谷校区E10-222阶梯教室

Venue: E10-222, Yungu Campus

主持人：西湖大学生命科学学院 副教授贾洁敏

Host: Associate Professor Jie-Min JIA, School of Life Sciences

主讲人/Speaker：

Tony Wyss-Coray

D. H. Chen Professor of Neurology and Neurological Sciences

Director, Phil and Penny Knight Initiative for Brain Resilience

Stanford University, California, USA

Tony Wyss-Coray is the D.H. Chen Distinguished Professor of Neurology and Neurological Sciences and the Director of the Phil and Penny Knight Initiative for Brain Resilience at Stanford University. His lab studies brain aging and neurodegeneration with a focus on age-related cognitive decline and Alzheimer’s disease. The Wyss-Coray research team discovered that circulatory blood factors can modulate brain structure and function and factors from young organisms can rejuvenate old brains. Current studies focus on the molecular basis of the systemic communication with the brain by employing a combination of genetic, cell biology, and omics approaches in killifish, mice, and humans.Wyss-Coray has presented his ideas at Global TED, the Tencent WE Summit, and the World Economic Forum, and he was voted Time Magazine’s “The Health Care 50” most influential people transforming health care in 2018. He co-founded Alkahest Inc. and several other companies targeting Alzheimer’s and neurodegeneration and has been the recipient of an NIH Director’s Pioneer Award, a Zenith Award from the Alzheimer’s Association, and a NOMIS Foundation Award.

报告题目/Title:

Young blood for old brains

讲座摘要/Abstract:

Aging leads to the degradation of function in nearly all tissues and organs. This process is marked by significant shifts in gene expression and changes in concentrations of all types of biological molecules. Recent technological progress has allowed scientists to measure an unprecedented number of these molecules throughout an organism, providing unique insights into the physiological and pathological conditions of cells and organs, including the aging process.

Large scale proteomic studies in humans demonstrate dramatic changes in the composition of blood and cerebrospinal fluid proteomes with age allowing us to estimate brain age and identify proteins linked to cognitive decline, neurodegeneration, and dementia. While brain cell- and tissue-intrinsic factors are likely essential in driving the aging process we find blood borne factors from young humans and mice are sufficient to counteract aspects of brain aging and improve cognitive function in old mice while blood plasma from old organisms is detrimental to young mice and impairs their cognition. These findings open opportunities to identify biomarkers and regulators of aging in general and for brain and other organs specifically.

讲座联系人/Contact:

科技合作部 sci-tech02@westlake.edu.cn